Random variation in rectal position during radiotherapy for prostate cancer is two to three times greater than that predicted from prostate motion.
Random variation in rectal position during radiotherapy for prostate cancer is two to three times greater than that predicted from prostate motion.
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DOI：
10.1259/bjr.20140343
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发表时间：
2014-10
期刊：
影响因子：
--
通讯作者：
Burnet N
中科院分区：
文献类型：
--
作者：
Scaife J;Harrison K;Romanchikova M;Parker A;Sutcliffe M;Bond S;Thomas S;Freeman S;Jena R;Bates A;Burnet N
前列腺癌的放射治疗没有明确考虑直肠位置的每日变化。为了了解剂量与毒性之间的关系，准确评估直肠累积剂量（DA）非常重要。这项工作的主要目的是量化系统（）和随机（σ）的变化，在前列腺放疗过程中的直肠位置。在千伏规划扫描和37次每日兆伏图像引导扫描上手动勾画10名参与VoxTox研究的参与者的直肠轮廓。股骨头用于产生所有直肠轮廓参考的固定点。计划和治疗之间的平均值标准差（SD）在前后（AP）方向为4.2 mm，左右（LR）方向为1.3 mm。σ（SD的均方根）为5.2 mm AP和2.7 mm LR。上下变异小于计划位置上下一层。我们的研究结果与前列腺运动的已发表数据一致。然而，σ大约是前列腺运动的两倍。这表明，DA可能与计划剂量不同，在一些患者接受放射治疗的前列腺癌。这项工作是第一次使用日常成像来量化前列腺癌直肠的Σ和σ。发现σ大于已发表的数据，为进一步研究个体DA提供了强有力的依据。
Radiotherapy for prostate cancer does not explicitly take into account daily variation in the position of the rectum. It is important to accurately assess accumulated dose (DA) to the rectum in order to understand the relationship between dose and toxicity. The primary objective of this work was to quantify systematic (Σ) and random (σ) variation in the position of the rectum during a course of prostate radiotherapy. The rectum was manually outlined on the kilo-voltage planning scan and 37 daily mega-voltage image guidance scans for 10 participants recruited to the VoxTox study. The femoral heads were used to produce a fixed point to which all rectal contours were referenced. Σ [standard deviation (SD) of means] between planning and treatment was 4.2 mm in the anteroposterior (AP) direction and 1.3 mm left–right (LR). σ (root mean square of SDs) was 5.2 mm AP and 2.7 mm LR. Superior–inferior variation was less than one slice above and below the planning position. Our results for Σ are in line with published data for prostate motion. σ, however, was approximately twice as great as that seen for prostate motion. This suggests that DA may differ from planned dose in some patients treated with radiotherapy for prostate cancer. This work is the first to use daily imaging to quantify Σ and σ of the rectum in prostate cancer. σ was found to be greater than published data, providing strong rationale for further investigation of individual DA.
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DOI：
10.1016/j.ijrobp.2009.09.040
发表时间：
2010-03-01
影响因子：
7
作者：
Bentzen, Soren M.;Constine, Louis S.;Deasy, Joseph O.;Eisbruch, Avi;Jackson, Andrew;Marks, Lawrence B.;Ten Haken, Randall K.;Yorke, Ellen D.
通讯作者：
Yorke, Ellen D.
影响因子：
5.7
作者：
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通讯作者：
Ma, C. M. Charlie
DOI：
10.1016/j.ijrobp.2008.07.002
发表时间：
2008-11-01
影响因子：
7
作者：
Bylund, Kevin C.;Bayouth, John E.;Buatti, John M.
通讯作者：
Buatti, John M.
影响因子：
5.7
作者：
Fiorino, C;Reni, M;Calandrino, R
通讯作者：
Calandrino, R
影响因子：
2.6
作者：
Jena, R.;Kirkby, N. F.;Burnet, N. G.
通讯作者：
Burnet, N. G.