Selective Vaporization of Superheated Nanodroplets for Rapid, Sensitive, Acoustic Biosensing.
Selective Vaporization of Superheated Nanodroplets for Rapid, Sensitive, Acoustic Biosensing.
复制标题
对快速，敏感，声学生物传感的过热纳米圆柱的选择性蒸发。
DOI：
10.1002/adhm.201500315
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发表时间：
2015-08-26
影响因子：
10
通讯作者：
Goodwin AP
中科院分区：
文献类型：
--
作者：
Chattaraj R;Mohan P;Besmer JD;Goodwin AP
过热的全氟化碳纳米液滴有望成为敏感的声学生物传感器。链霉亲和素对生物素修饰的脂质壳液滴的聚集大大增加了超声诱导汽化形成的气泡的产量。链霉亲和素的检测浓度低至 100 fM，可微信号在短短两分钟内出现，使用可扩展的检测，无需清洗、处理或开发步骤。
Superheated perfluorocarbon nanodroplets exhibit promise as sensitive acoustic biosensors. Aggregation of biotin-decorated lipid-shelled droplets by streptavidin greatly increased the yield of bubbles formed by ultrasound-induced vaporization. Streptavidin was sensed down to 100 fM, with differentiable signal appearing in as little as two minutes, using a scalable assay without washing, processing, or development steps.