Arsenic in drinking water and bladder cancer mortality in the United States: An analysis based on 133 US counties and 30 years of observation
Arsenic in drinking water and bladder cancer mortality in the United States: An analysis based on 133 US counties and 30 years of observation
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DOI：
10.1097/01.jom.0000116801.67556.8f
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发表时间：
2004-03-01
影响因子：
3.2
通讯作者：
Wilson, R
中科院分区：
文献类型：
--
作者：
Lamm, SH;Engel, A;Wilson, R
本研究分析饮水砷暴露与膀胱癌死亡率的关系。特定县的白色男性膀胱癌死亡率数据（1950-1979年）和特定县的地下水砷浓度数据，获得了133个美国县，已知完全依赖地下水为他们的公共饮用水供应。使用分层分析和回归分析（未加权和按县人口加权，并使用平均和中位数砷浓度），在3至60 μ g/L的暴露范围内，未发现与砷相关的膀胱癌死亡率增加。这些结果提供了美国居民砷相关癌症风险的直接估计，排除了国家研究理事会2001年的风险估计，该风险估计基于台湾西南部的数据，并需要调整美国和台湾居民的体重和水消耗率之间的差异。
This study analyzes the relationship between arsenic exposure through drinking water and bladder cancer mortality. The county-specific white male bladder cancer mortality data (1950-1979) and county-specific groundwater arsenic concentration data were obtained for 133 U.S. counties known to be exclusively dependent on groundwater for their public drinking water supply. No arsenic-related increase in bladder cancer mortality was found over the exposure range of 3 to 60 mug/L using stratified analysis and regression analyses (both unweighted and weighted by county population and using both mean and median arsenic concentrations). These results, which provide a direct estimate of arsenic-related cancer risk for U.S. residents, exclude the National Research Council's 2001 risk estimate that was based on Southwest Taiwan data and required adjusting for differences between the body mass and water consumption rates of U.S. and Taiwanese residents.