The role of S100 genes in breast cancer progression
The role of S100 genes in breast cancer progression
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DOI：
10.1007/s13277-010-0137-2
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发表时间：
2011-06-01
期刊：
影响因子：
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通讯作者：
Duffy, Michael J.
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文献类型：
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作者：
McKiernan, Eadaoin;McDermott, Enda W.;Duffy, Michael J.
S100基因家族编码与癌症进展有关的低分子蛋白质。在这项研究中，我们分析了四个S100基因在一个乳腺癌患者队列中的表达，以及16个S100基因在第二个队列中的表达。在这两组病例中，S100A8和S1009mRNA的表达水平在高级别肿瘤中高于低级别肿瘤，在雌激素受体阴性的肿瘤中高于雌激素受体阳性的肿瘤。在所研究的S100转录本中，没有一个与淋巴转移的存在显著相关。值得注意的是，多个S100基因，包括S100A1、S100A2、S100A4、S100A6、S100A8、S100A9、S100A10、S100A11和S100A14在基底型乳腺癌中较非基底型乳腺癌上调。经Spearman相关分析，S100转录本之间的相关性显著，其中S100A8与S100A9的相关性最强(r=0.889，P<；0.001，n=295)。在调查的16个S100转录本中，只有S100A11和S100A14与患者预后显著相关。事实上，这两个转录本预测了没有接受系统辅助治疗的患者队列的结果。根据我们的发现，我们得出结论，不同的S100基因在乳腺癌进展中扮演着不同的角色。特异性S100基因是治疗基底细胞型乳腺癌的潜在靶点。
The S100 gene family encode low molecular weight proteins implicated in cancer progression. In this study, we analyzed the expression of four S100 genes in one cohort of patients with breast cancer and 16 S100 genes in a second cohort. In both cohorts, the expression of S100A8 and S1009 mRNA level was elevated in high-grade compared to low-grade tumors and in estrogen receptor-negative compared to estrogen receptor-positive tumors. None of the S100 transcripts investigated were significantly associated with the presence of lymph node metastasis. Notably, multiple S100 genes, including S100A1, S100A2, S100A4, S100A6, S100A8, S100A9, S100A10, S100A11, and S100A14 were upregulated in basal-type breast cancers compared to non-basal types. Using Spearman's correlation analysis, several S100 transcripts correlated significantly with each other, the strongest correlation has been found between S100A8 and S100A9 (r = 0.889, P < 0.001, n = 295). Of the 16 S100 transcripts investigated, only S100A11 and S100A14 were significantly associated with patient outcome. Indeed, these two transcripts predicted outcome in the cohort of patients that did not receive systemic adjuvant therapy. Based on our findings, we conclude that the different S100 genes play varying roles in breast cancer progression. Specific S100 genes are potential targets for the treatment of basal-type breast cancers.