Fungal sex genes - searching for the ancestors
Fungal sex genes - searching for the ancestors
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DOI：
10.1002/bies.20782
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发表时间：
2008-08-01
期刊：
影响因子：
4
通讯作者：
Casselton, Lorna A.
中科院分区：
文献类型：
--
作者：
Casselton, Lorna A.
真菌的性别决定基因位于染色体的一个或两个特定区域，称为交配型（MAT）基因座。这些基因足以决定单倍体细胞的身份，使相容的交配伴侣能够相互吸引，并为受精后的有性生殖做好准备。这些基因在不同的真菌群中有多保守？新的工作（（1））通过确定早期分歧真菌的性别决定区域来寻求这个问题的答案。这些区域与其他真菌中描述的区域具有显着的相似性，但它们编码的性蛋白只属于一类转录因子，即高迁移率族（HMG），这表明这些蛋白可能是其他真菌性蛋白的祖先。
The sex-determining genes of fungi reside at one or two specialised regions of the chromosome known as the mating type (MAT) loci. The genes are sufficient to determine haploid cell identity, enable compatible mating partners to attract each other, and prepare cells for sexual reproduction after fertilisation. How conserved are these genes in different fungal groups? New work((1)) seeks an answer to this question by identifying the sex-determining regions of an early diverged fungus. These regions bear remarkable similarity to those described in other fungi, but the sex proteins they encode belong to only a single class of transcription factor, the high mobility group (HMG), indicating that these are likely to be ancestral to other proteins recruited for fungal sex.