Intrinsic function of a neuronal network -: a vertebrate central pattern generator
Intrinsic function of a neuronal network -: a vertebrate central pattern generator
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DOI：
10.1016/s0165-0173(98)00002-2
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发表时间：
1998-05-01
影响因子：
--
通讯作者：
Wallén, P
中科院分区：
文献类型：
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作者：
Grillner, S;Ekeberg, Ö;Wallén, P
使用七lamp虫作为模型系统审查脊椎动物运动行为的细胞底座。前脑和脑干细胞种群通过网状脊髓纤维激活由谷氨酸能和糖苷能中间神经元组成的脊柱网络引发运动活性。 Ca2+通道的不同亚型，Ca2+依赖性K+通道和依赖性NMDA通道在神经元和网络水平上的作用以及靶向这些离子通道的不同代谢性，AMINEGROPIC和肽型调节剂的影响。这是在细胞水平上理解的少数脊椎动物网络之一。 （c）1998 Elsevier Science B.V.保留所有权利。
The cellular bases of vertebrate locomotor behaviour is reviewed using the lamprey as a model system. Forebrain and brainstem cell populations initiate locomotor activity via reticulospinal fibers activating a spinal network comprised of glutamatergic and glycinergic interneurons. The role of different subtypes of Ca2+ channels, Ca2+ dependent K+ channels and voltage dependent NMDA channels at the neuronal and network level is in focus as well as the effects of different metabotropic, aminergic and peptidergic modulators that target these ion channels. This is one of the few vertebrate networks that is understood at a cellular level. (C) 1998 Elsevier Science B.V. All rights reserved.