Quantitative Structure-Retention Relationship Studies with Biopartitioning Micellar Chromatography Systems by Amended Linear Solvation Energy Relationships in Consideration of Electronic Factor
Quantitative Structure-Retention Relationship Studies with Biopartitioning Micellar Chromatography Systems by Amended Linear Solvation Energy Relationships in Consideration of Electronic Factor
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考虑电子因素的修正线性溶剂化能关系对生物分配胶束色谱系统的定量结构保留关系研究
DOI：
10.1365/s10337-009-1150-8
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发表时间：
2009-05
期刊：
影响因子：
1.7
通讯作者：
Wang, Yongjun
中科院分区：
文献类型：
--
作者：
Lu, Rong;He, Zhonggui;Sun, Jin;Wang, Yongjun
Linear solvation energy relationship (LSER) amended by the introduction of a molecular electronic factor was employed to establish quantitative structure-retention relationship of biopartitioning micellar chromatography (BMC) system. The chromatographic indices, logk, were determined by LC on a C18 column for sixty-five structurally diverse compounds, including neutral (32), acidic (19) and basic (14) compounds. Two micellar mobile phases composed of 0.04 mol L−1polyoxyethylene (23) lauryl ether (Brij35) were adjusted by phosphate buffer to pH 7.4 and pH 6.5, respectively. When the mean net charge per molecule (δ) was introduced into LSER as the sixth variable, the LSER regression coefficients and predictive capability were significantly improved. However, theδcoefficients of the amended LSER were quite different for acidic and basic compounds, indicating that the molecular electronic factor had a markedly different impact on the retention of acidic and basic compounds in the studied BMC system. This may attribute to the extra interaction for ionized compounds with the free silanol groups in the stationary phase. The comparison of calculated and experimental retention indices suggested that the amended LSER could reproduce adequately the retention of the structurally diverse solutes investigated in BMC.
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影响因子：
6.7
作者：
Yuan H. Zhao;M. Abraham;A. Hersey;C. Luscombe
通讯作者：
Yuan H. Zhao;M. Abraham;A. Hersey;C. Luscombe
DOI：
10.1002/bmc.432
发表时间：
2005-03
期刊：
Biomedical chromatography : BMC
影响因子：
--
作者：
L. Escuder-Gilabert;S. Sagrado;R. Villanueva-Camañas;M. Medina-Hernández
通讯作者：
L. Escuder-Gilabert;S. Sagrado;R. Villanueva-Camañas;M. Medina-Hernández
DOI：
10.1016/s0378-4347(00)00546-6
发表时间：
2001-04-05
期刊：
JOURNAL OF CHROMATOGRAPHY B
影响因子：
--
作者：
Molero-Monfort, M;Escuder-Gilabert, L;Medina-Hernández, MJ
通讯作者：
Medina-Hernández, MJ
DOI：
10.1016/j.jchromb.2004.04.004
发表时间：
2004-08-05
影响因子：
3
作者：
Escuder-Gilabert, L;Molero-Monfort, A;Medina-Hernández, MJ
通讯作者：
Medina-Hernández, MJ
影响因子：
4.1
作者：
Li, Jie;Sun, Jin;He, Zhonggui
通讯作者：
He, Zhonggui