Spontaneous intracranial hypotension-hypovolemia associated with tacrolimus.
Spontaneous intracranial hypotension-hypovolemia associated with tacrolimus.
复制标题
与他克莫司相关的自发性颅内低血压-低血容量。
DOI：
10.1111/j.1526-4610.2010.01701.x
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发表时间：
2010
期刊：
影响因子：
5
通讯作者：
Dillon,WilliamP
中科院分区：
文献类型：
--
作者：
Ahn,AndrewH;Berman,BrianD;Dillon,WilliamP
药物诱导的自发性颅内低血压/脑脊液（CSF）血容量减少（SIH）的先例很少。该女性病例的CSF压力低、直立性头痛和影像学检查结果与SIH一致，但没有可检测到的渗漏，值得注意的是其发作和消退均与钙调磷酸酶抑制剂他克莫司（FK 506）的使用相关。关于他克莫司诱导的CSF低血压的潜在原因的文献综述提示了许多潜在的作用机制，包括对血脑屏障和硬脑膜顺应性的影响，并支持在他克莫司使用的医学复杂背景下对这种情况进一步警惕。
There is little precedent for a medication‐induced spontaneous intracranial hypotension/cerebrospinal fluid (CSF) hypovolemia (SIH). This case history of a woman with low CSF pressure, orthostatic headache, and radiographic findings consistent with SIH but without a detectable leak was notable for its association, both onset and resolution, with the use of the calcineurin inhibitor tacrolimus (FK506). A literature review for potential causes of a tacrolimus‐induced CSF hypotension suggests many potential mechanisms of action, including effects on blood brain barrier and dural compliance, and supports further vigilance for this condition in the medically complex setting of tacrolimus use.