Joint effects of mitochondrial DNA 5178 C/A polymorphism and coffee consumption or alcohol consumption on clustering of cardiovascular risk factors in middle-aged Japanese men: a cross-sectional study.
Joint effects of mitochondrial DNA 5178 C/A polymorphism and coffee consumption or alcohol consumption on clustering of cardiovascular risk factors in middle-aged Japanese men: a cross-sectional study.
复制标题
DOI：
10.1186/2251-6581-13-4
复制
发表时间：
2014-01-06
影响因子：
2.8
通讯作者：
Takashima Y
中科院分区：
文献类型：
--
作者：
Ito T;Kokaze A;Ishikawa M;Matsunaga N;Karita K;Yoshida M;Ohtsu T;Ochiai H;Shirasawa T;Nanri H;Hoshino H;Takashima Y
据报道，长寿相关的线粒体DNA 5178（Mt5178）C/A调节咖啡消费对高血压，血脂异常和葡萄糖耐量异常的风险的影响，以及饮酒对高血压，血脂异常和高尿酸血症的风险的影响。然而，还没有研究探讨Mt5178 C/A多态性是否影响咖啡或酒精消费对心血管危险因素（CRF）聚集的影响。从定期到医院进行体检的个体中选择了共计332名男性受试者（平均年龄± SD，52.8 ± 7.8岁）。在Mt5178 C/A基因分型后，然后进行横断面研究，评估Mt5178 C/A多态性和咖啡或酒精消耗对CRF聚集的联合作用，即高血压、异常葡萄糖耐量、高低密度脂蛋白胆固醇血症、低高密度脂蛋白胆固醇血症、高甘油三酯血症和高尿酸血症。调整混杂因素后，在Mt5178 C受试者中观察到咖啡摄入量与≥2个CRF聚集之间存在显著和负相关性。每天饮用1-3杯咖啡的受试者中，≥2个或≥3个CRF聚集的校正比值比（OR）显著低于每天饮用<1杯咖啡的受试者（分别为OR = 0.496，95%置信区间（CI）：0.249-0.989和OR = 0.369，95% CI：0.165-0.826）。另一方面，校正后，在Mt5178 A受试者中观察到咖啡摄入量与≥2个CRF聚集之间的正相关性。然而，这些关联并未达到显著水平。对于Mt5178 C基因型男性，每日饮酒者中≥2个或≥3个CRF聚集的校正OR显著高于偶尔饮酒者（OR = 2.737，95%CI：1.361-5.502; OR = 3.024，95%CI：1.269-7.210）。另一方面，Mt5178 A基因型与≥2或≥3个CRF的聚集之间的关联似乎不依赖于饮酒。目前的研究结果表明，Mt5178 C/A多态性修改的影响，咖啡消费或酒精消费的聚集CRF在中年日本男性。
Longevity-associated mitochondrial DNA 5178 (Mt5178) C/A reportedly modulates the effects of coffee consumption on the risk of hypertension, dyslipidemia and abnormal glucose tolerance, and those of alcohol consumption on the risk of hypertension, dyslipidemia and hyperuricemia in middle-aged Japanese men. However, there has been no research examining whether Mt5178 C/A polymorphism influences the effects of coffee consumption or alcohol consumption on the clustering of cardiovascular risk factors (CRFs). A total of 332 male subjects (mean age ± SD, 52.8 ± 7.8 years) were selected from among individuals visiting the hospital for regular medical check-ups. After Mt5178 C/A genotyping, a cross-sectional study assessing the joint effects of Mt5178 C/A polymorphism and coffee consumption or alcohol consumption on the clustering of CRFs, namely hypertension, abnormal glucose tolerance, hyper-low-density lipoprotein cholesterolemia, hypo-high density lipoprotein cholesterolemia, hypertriglyceridemia and hyperuricemia, was then conducted. After adjustment for confounding factors, significant and negative associations were observed between coffee consumption and clustering of ≥2 CRFs in subjects with Mt5178C. The adjusted odds ratio (OR) for the clustering of ≥2 or ≥3 CRFs was significantly lower in subjects who consumed 1–3 cups of coffee per day than in those who consumed <1 cup of coffee per day (OR = 0.496, 95% confidence interval (CI): 0.249–0.989, and OR = 0.369, 95% CI: 0.165–0.826, respectively). On the other hand, after adjustment, positive associations between coffee consumption and clustering of ≥2 CRFs were observed in subjects with Mt5178A. However, these associations did not reach a significant level. For Mt5178C genotypic men, the adjusted OR for the clustering of ≥2 or ≥3 CRFs was significantly higher in daily drinkers than in occasional drinkers (OR = 2.737, 95% CI: 1.361–5.502, and OR = 3.024, 95% CI: 1.269–7.210, respectively). On the other hand, the association between Mt5178A genotype and the clustering of ≥2 or ≥3 CRFs did not appear to depend on alcohol consumption. The present results suggest that Mt5178 C/A polymorphism modifies the effects of coffee consumption or alcohol consumption on the clustering of CRFs in middle-aged Japanese men.