Effects of Fimbria-Fornix Lesions on Door Discrimination and Route Choice in a Lattice Maze by Rats
Effects of Fimbria-Fornix Lesions on Door Discrimination and Route Choice in a Lattice Maze by Rats
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穹窿伞部损伤对大鼠格子迷宫门辨别和路线选择的影响
DOI：
10.1006/nlme.1996.0056
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发表时间：
1996
影响因子：
2.7
通讯作者：
H. Okaichi
中科院分区：
文献类型：
--
作者：
H. Okaichi
本实验讨论了（1）“认知地图”在大鼠中的应用，通过显示它们能够在迷宫中的给定位置确定自己和它们的运动方向;（2）海马在空间认知中的作用，通过检查海马损伤对执行迷宫任务的大鼠的影响。所采用的装置是由正交交叉的八条小巷组成的格子迷宫。这些小巷被总共24扇显然相同的门隔开; 8扇门上了锁，其他的门没有上锁。穹窿海马伞损伤（FF）（n = 16）和对照组（n = 18）雄性Wistar大鼠进行训练，从四个开始框之一运行的目标，在开放和封闭的条件下，一个显着的视觉提示。OPEN-Cont组的大鼠成功区分了上锁和未上锁的门，并且能够选择绕道路线和最短路线。这被认为是他们形成认知地图能力的证据。封闭-对照组的大鼠没有迷宫内或迷宫外的线索，但也能够学习任务。有人提出，他们使用本体感受线索形成认知地图，使他们能够解决问题。FF组的大鼠无法避免上锁的门，因为它们无法形成认知地图。然而，他们利用目标刺激作为线索来解决问题。
The present experiment discusses (1) the use of "cognitive maps" in rats by showing that they can orient themselves and their direction of movement at a given place in a maze and (2) the role of the hippocampus in spatial cognition by examining the effects of hippocampal lesions on rats performing maze tasks. The apparatus employed was a lattice maze consisting of eight alleys which cross orthogonally. The alleys were partitioned by a total of 24 apparently identical doors; 8 doors were locked and the others were unlocked. Fimbria-fornix-lesioned (FF) (n = 16) and control (n = 18) male Wistar rats were trained to run from one of four start boxes to the goal with a salient visual cue under open and closed conditions. Rats in the OPEN-Cont group successfully discriminated between locked and unlocked doors and were able to choose detour routes as well as the shortest route. This was regarded as evidence of their ability to form a cognitive map. Rats in the CLOSED-Cont group did not have intra- or extramaze cues but were also able to learn the task. It is proposed that they used proprioceptive cues to form cognitive maps, which enabled them to solve the problem. Rats in the FF group could not avoid locked doors because they were not able to form cognitive maps. However, they utilized the goal stimulus as a cue to solve the problem.