Green tea catechins and cardiovascular health: an update.
Green tea catechins and cardiovascular health: an update.
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DOI：
10.2174/092986708785132979
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发表时间：
2008-07
影响因子：
4.1
通讯作者：
P. V. A. Babu;Dongmin Liu
中科院分区：
文献类型：
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作者：
P. V. A. Babu;Dongmin Liu
流行病学，临床和实验研究已经建立了绿色茶消费和心血管健康之间的正相关性。儿茶素是绿色茶中的主要多酚类化合物，通过多种机制发挥血管保护作用，包括抗氧化、抗高血压、抗炎、抗增殖、抗血栓形成和降脂作用。(1)茶儿茶素通过清除自由基、螯合氧化还原活性过渡金属离子、抑制氧化还原活性转录因子、抑制促氧化酶和诱导抗氧化酶而发挥抗氧化活性。(2)茶儿茶素抑制参与脂质生物合成的关键酶，减少肠道脂质吸收，从而改善血脂谱。(3)儿茶素通过激活内皮一氧化氮调节血管张力。(4)儿茶素可预防血管炎症，而血管炎症在动脉粥样硬化病变的进展中起着关键作用。儿茶素的抗炎活性可能是由于它们通过抑制转录因子NF-κ B介导的内皮细胞和炎症细胞中细胞因子和粘附分子的产生来抑制白细胞粘附到内皮和随后的迁移。(5)儿茶素通过干扰参与动脉粥样硬化形成的血管细胞生长因子抑制血管平滑肌细胞增殖。(6)儿茶素抑制血小板粘附，从而抑制血栓形成。因此，儿茶素类化合物可能是一种新型的植物源性小分子化合物，可用于心血管疾病的预防和治疗。本文综述了绿色茶提取物和血管健康的最新进展，特别关注茶儿茶素在预防各种血管疾病中的作用及其作用机制。此外，还讨论了儿茶素类化合物可能的构效关系。
Epidemiological, clinical and experimental studies have established a positive correlation between green tea consumption and cardiovascular health. Catechins, the major polyphenolic compounds in green tea, exert vascular protective effects through multiple mechanisms, including antioxidative, anti-hypertensive, anti-inflammatory, anti-proliferative, anti-thrombogenic, and lipid lowering effects. (1) Tea catechins present antioxidant activity by scavenging free radicals, chelating redox active transition-metal ions, inhibiting redox active transcription factors, inhibiting pro-oxidant enzymes and inducing antioxidant enzymes. (2) Tea catechins inhibit the key enzymes involved in lipid biosynthesis and reduce intestinal lipid absorption, thereby improving blood lipid profile. (3) Catechins regulate vascular tone by activating endothelial nitric oxide. (4) Catechins prevent vascular inflammation that plays a critical role in the progression of atherosclerotic lesions. The anti-inflammatory activities of catechins may be due to their suppression of leukocyte adhesion to endothelium and subsequent transmigration through inhibition of transcriptional factor NF-kB-mediated production of cytokines and adhesion molecules both in endothelial cells and inflammatory cells. (5) Catechins inhibit proliferation of vascular smooth muscle cells by interfering with vascular cell growth factors involved in atherogenesis. (6) Catechins suppress platelet adhesion, thereby inhibiting thrombogenesis. Taken together, catechins may be novel plant-derived small molecules for the prevention and treatment of cardiovascular diseases. This review highlights current developments in green tea extracts and vascular health, focusing specifically on the role of tea catechins in the prevention of various vascular diseases and the underlying mechanisms for these actions. In addition, the possible structure-activity relationship of catechins is discussed.