Conversion of mouse mammary tumor virus to a lymphomagenic virus
Conversion of mouse mammary tumor virus to a lymphomagenic virus
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DOI：
10.1128/jvi.79.19.12592-12596.2005
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发表时间：
2005-10-01
影响因子：
5.4
通讯作者：
Dudley, JP
中科院分区：
文献类型：
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作者：
Bhadra, S;Lozano, MM;Dudley, JP
B型白血病病毒是小鼠乳腺肿瘤病毒(MMTV)的变种，它会导致小鼠的胸腺淋巴瘤，而不是乳腺肿瘤。我们证明，将嗜乳性MMTV转换为嗜T细胞病毒需要在长末端重复序列中发生两个变化：(I)获得T细胞特异性增强子和(Ii)通过删除负调控元件(NRES)或通过适当定位增强子后抑制NRE活性而失去转录抑制。
Type B leukemogenic virus is a variant of mouse mammary tumor virus (MMTV) that causes thymic lymphomas rather than mammary tumors in mice. We demonstrate that conversion of a mammotropic MMTV to a T-cell-tropic virus requires two alterations in the long terminal repeat: (i) acquisition of a T-cell-specific enhancer and (ii) loss of transcriptional repression through deletion of negative regulatory elements (NREs) or by suppression of NRE activity after appropriate positioning of the enhancer.