Melanopsin in cells of origin of the retinohypothalamic tract
Melanopsin in cells of origin of the retinohypothalamic tract
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DOI：
10.1038/nn768
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发表时间：
2001-12-01
影响因子：
25
通讯作者：
Saper, CB
中科院分区：
文献类型：
--
作者：
Gooley, JJ;Lu, J;Saper, CB
所有已知的真核生物都表现出被称为昼夜节律的生理和行为节律，周期接近24小时；在哺乳动物中，光是将内源性节律带入每日光循环的最有力刺激物。光信息通过视网膜下丘脑束（RHT）传递到下丘脑的视交叉上核（SCN），在那里产生昼夜节律，但介导昼夜节律的视网膜光色素仍然难以捉摸。在这里，我们发现大多数视网膜神经节细胞（RGCs）投射到SCN表达光色素黑视素。
All known eukaryotic organisms exhibit physiological and behavioral rhythms termed circadian rhythms that cycle with a near-24-hour period; in mammals, light is the most potent stimulus for entraining endogenous rhythms to the daily light cycle. Photic information is transmitted via the retinohypothalamic tract (RHT) to the suprachiasmatic nucleus (SCN) in the hypothalamus, where circadian rhythms are generated, but the retinal photopigment that mediates circadian entrainment has remained elusive. Here we show that most retinal ganglion cells (RGCs) that project to the SCN express the photopigment melanopsin.