PROGNOSTIC FACTORS IN BREAST-CANCER
PROGNOSTIC FACTORS IN BREAST-CANCER
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DOI：
10.1002/ssu.2980050206
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发表时间：
1989-01-01
期刊：
影响因子：
--
通讯作者：
CLARK, GM
中科院分区：
文献类型：
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作者：
SAEZ, RA;MCGUIRE, WL;CLARK, GM
有几个独立但又相互关联的预后因素可以预测乳腺癌的复发和生存。这些包括腋窝结节状态、组织病理学、类固醇受体、增殖率、倍体和癌基因扩增。腋窝淋巴结状态一直是预测乳腺癌复发和生存的传统主要指标。此外，雌激素和孕激素受体的存在与I期和II期乳腺癌较长的无病间隔和总存活率相关。胸腺嘧啶核苷标记指数和流式细胞术检测的S期细胞百分比是绝经前和绝经后乳腺癌患者细胞增殖与复发率相关的指标。雌激素和孕激素受体阴性的肿瘤更常见的是非整倍体，并且有较高的S期比例，这是预测I期乳腺癌复发的因素。
There are several independent but interrelated prognostic factors predictive of recurrence and survival in breast cancer. These include axillary nodal status, histopathology, steroid receptors, proliferative rate, ploidy, and oncogene amplification. Axillary nodal status has been the traditional mainstay predictor for recurrence and survival in primary breast cancer. In addition, the presence of the estrogen and progesterone receptors has correlated with longer disease‐free interval and overall survival in stage I and II breast cancer. Thymidine‐labeling index and percent S‐phase as measured by flow cytometry are indices of cell proliferation that correlate with relapse rate in pre‐ and postmenopausal women with breast cancer. Estrogen and progesterone receptor‐negative tumors are more commonly aneuploid, and have higher percent S‐phase, factors that predict for recurrence in Stage I breast cancer.