Kynurenic acid distinguishes kainate and quisqualate receptors in the vertebrate retina.
Kynurenic acid distinguishes kainate and quisqualate receptors in the vertebrate retina.
复制标题
犬尿酸可区分脊椎动物视网膜中的红藻氨酸和使君子酸受体。
DOI：
10.1016/0006-8993(86)90708-0
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发表时间：
1986
期刊：
影响因子：
2.9
通讯作者：
Miller,RF
中科院分区：
文献类型：
--
作者：
Coleman,PA;Massey,SC;Miller,RF
Excitatory amino acid receptors (EAARs) underlie major synaptic pathways in the brain, retina and spinal cord. Several subclasses of EAARs have been proposed, based on pharmacological studies using a variety of agonists and antagonists. Kynurenic acid (Kyn), a metabolite of tryptophan, has been recently proposed as a potent EAAR antagonist. In this report, we show that Kyn can be used to separate two distinct classes of EAAR in the vertebrate retina: it blocks kainic acid (KA) responses but has minimal effects on responses mediated by quisqualate (QQ). At concentrations which block the KA responses, Kyn also blocks the light-evoked synaptic responses of all types of third-order neurons in the retina. These results suggest that KA receptors are the major receptor subtypes which underlie synaptic transmission and that QQ receptors are minimally utilized by light-activated pathways under the conditions of our experiments.
