Right Posterior Insula and Putamen Volume Mediate the Effect of Oxytocin Receptor Polygenic Risk for Autism Spectrum Disorders on Reward Dependence in Healthy Adults
Right Posterior Insula and Putamen Volume Mediate the Effect of Oxytocin Receptor Polygenic Risk for Autism Spectrum Disorders on Reward Dependence in Healthy Adults
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右后岛叶和壳核体积介导自闭症谱系障碍催产素受体多基因风险对健康成人奖励依赖的影响
DOI：
10.1093/cercor/bhaa198
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Chunshui Yu
中科院分区：
文献类型：
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作者：
Junping Wang;Peng Zhang;Wei Li;Wen Qin;Feng Liu;Jiayuan Xu;Qiang Xu;Dan Zhu;Zhaoxiang Ye;Chunshui Yu
许多证据表明，催产素受体（OXTR）基因对自闭症谱系障碍（ASDs）的影响，ASDs是一组以一系列亲社会行为缺陷为特征的障碍，其与奖励依赖（RD）人格特质密切相关。然而，我们不知道自闭症多基因风险评分（OXTR-PRSASDs）对RD及其潜在的神经解剖学基础的影响。在这里，我们的目的是在两个独立的健康年轻人数据集（n= 450和540）中调查oxtr - prsasds、灰质体积（GMV）和RD之间的关系。我们发现，oxtr - prsas较高的个体在右侧后岛和壳核有较低的RD和显著较小的GMV。该区域的GMV与RD呈正相关，并在oxtr - prsasds与RD之间存在中介作用，且oxtr - prsasds与GMV的相关图谱与thoxtrgene表达呈空间相关性。所有结果在两个数据集之间高度一致。这些发现强调了一种可能的神经通路，即与asd相关的oxtr基因的常见变异可能共同影响右侧后岛和壳核的GMV，并进一步影响RD的人格特质。
Much evidence indicates the influence of the oxytocin receptor (OXTR) gene on autism spectrum disorders (ASDs), a set of disorders characterized by a range of deficits in prosocial behaviors, which are closely related to the personality trait of reward dependence (RD). However, we do not know the effect of theOXTRpolygenic risk score for ASDs (OXTR-PRSASDs) on RD and its underlying neuroanatomical substrate. Here, we aimed to investigate associations among theOXTR-PRSASDs, gray matter volume (GMV), and RD in two independent datasets of healthy young adults (n= 450 and 540). We found that the individuals with higherOXTR-PRSASDshad lower RD and significantly smaller GMV in the right posterior insula and putamen. The GMV of this region showed a positive correlation with RD and a mediation effect on the association betweenOXTR-PRSASDsand RD. Moreover, the correlation map betweenOXTR-PRSASDsand GMV showed spatial correlation withOXTRgene expression. All results were highly consistent between the two datasets. These findings highlight a possible neural pathway by which the common variants in theOXTRgene associated with ASDs may jointly impact the GMV of the right posterior insula and putamen and further affect the personality trait of RD.