Usefulness and limitations of regional cardiac sympathectomy by phenol.
Usefulness and limitations of regional cardiac sympathectomy by phenol.
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苯酚局部心脏交感神经切除术的有用性和局限性。
DOI：
10.1152/ajpheart.1989.257.5.h1523
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Hoffman,JI
中科院分区：
文献类型：
--
作者：
Mori,H;Pisarri,TE;Aldea,GS;Husseini,WK;Dae,MW;Stevens,MB;Hill,AC;Coleridge,JC;Coleridge,HM;Hoffman,JI
我们评估了麻醉犬心外膜涂抹苯酚后左心室区域交感神经去支配的完整性和程度。在苯酚包围的区域中，电刺激传出交感神经纤维对心肌收缩力和冠状动脉血管阻力的影响在30分钟内被完全废除。去神经支配延伸到由交感神经纤维支配的未经处理的区域跨越苯酚线。苯酚应用后至少4小时，静脉输注异丙肾上腺素或冠状动脉输注酪胺增加失神经区域的心肌收缩力;去甲肾上腺素含量和神经递质摄取正常，表明神经末梢、连接后受体和心肌保持功能。3-14天后，围术区组织中的儿茶酚胺含量和递质摄取明显减少。结果表明，仔细的评估是必要的，在选择一个完全支配的控制区域的研究采用区域交感神经与苯酚。
We evaluated the completeness and extent of regional sympathetic denervation of the left ventricle after epicardial painting with phenol in anesthetized dogs. In a region encircled by phenol, the effect of electrical stimulation of efferent sympathetic fibers on myocardial contractility and coronary vascular resistance was completely abolished within 30 min. Denervation extended to untreated regions innervated by sympathetic fibers crossing the phenol line. For at least 4 h after phenol application, intravenous infusion of isoproterenol or coronary arterial infusion of tyramine increased myocardial contractility in the denervated region; norepinephrine content and neurotransmitter uptake were normal, indicating that nerve terminals, postjunctional receptors, and myocardium remained functional. However, after 3-14 days, tissue catecholamine content and transmitter uptake in the encircled area were markedly reduced. The results suggest that careful evaluation is necessary in selecting a fully innervated control region in studies employing regional sympathetic denervation with phenol.