GLUCAGON AND THE GLUCAGON-LIKE PEPTIDES
GLUCAGON AND THE GLUCAGON-LIKE PEPTIDES
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DOI：
10.1097/00006676-199007000-00018
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发表时间：
1990-07-01
期刊：
影响因子：
2.9
通讯作者：
DRUCKER, DJ
中科院分区：
文献类型：
--
作者：
DRUCKER, DJ
胰高血糖素和胰高血糖素样肽在较大的前体胰高血糖素原内编码。胰高血糖素原基因在胰腺、肠和脑中表达，产生在所有组织中都相同的单一胰高血糖素原 mRNA 转录物。胰高血糖素原的组织特异性翻译后加工解释了每个组织中存在的胰高血糖素相关肽的不同分子形式。胰高血糖素样肽 I 已被证明具有有效的促胰岛素特性，但其他胰高血糖素相关肽的生物学重要性仍不清楚。综述了增加我们对胰高血糖素和胰高血糖素样肽生物学了解的最新进展。
Glucagon and the glucagon-like peptides are encoded within a larger precursor, proglucagon. The proglucagon gene is expressed in the pancreas, intestine, and brain, giving rise to a single proglucagon mRNA transcript that is identical in all tissues. Tissue-specific posttranslational processing of proglucagon accounts for the different molecular forms of the glucagon-related peptides present in each tissue. Glucagon-like peptide I has been demonstrated to have potent insulinotropic properties, but the biological importance of other glucagon-related peptides remains unclear. The recent advances that have increased our understanding of the biology of glucagon and the glucagon-like peptides are reviewed.