New trends in articular cartilage repair.
New trends in articular cartilage repair.
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DOI：
10.1186/s40634-015-0026-0
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发表时间：
2015-12
影响因子：
1.8
通讯作者：
Madry H
中科院分区：
文献类型：
--
作者：
Cucchiarini M;Henrionnet C;Mainard D;Pinzano A;Madry H
关节软骨损伤是骨科医生面临的一个重要、普遍且尚未解决的临床问题。本文综述了创新的基础研究方法，可能会提高目前的理解软骨修复过程，并导致新的治疗方案。在这方面，软骨组织工程的新方面，重点是选择最合适的细胞来源。非破坏性软骨成像的重要性是突出与最近可用的适应实验工具，如二次谐波发生（SHG）成像。新的见解软骨病理生理学的基础上参与的髌下脂肪垫在骨关节炎也进行了描述。此外，重组腺相关病毒载体被讨论为临床适应，有效的工具，潜在的基因为基础的药物在各种关节软骨疾病。总的来说，在关节软骨修复的不同领域的基础研究中的这种进展可能会导致在不久的将来在临床上开发改进的疗法，以改善软骨病变的有效治疗。
Damage to the articular cartilage is an important, prevalent, and unsolved clinical issue for the orthopaedic surgeon. This review summarizes innovative basic research approaches that may improve the current understanding of cartilage repair processes and lead to novel therapeutic options. In this regard, new aspects of cartilage tissue engineering with a focus on the choice of the best-suited cell source are presented. The importance of non-destructive cartilage imaging is highlighted with the recent availability of adapted experimental tools such as Second Harmonic Generation (SHG) imaging. Novel insights into cartilage pathophysiology based on the involvement of the infrapatellar fat pad in osteoarthritis are also described. Also, recombinant adeno-associated viral vectors are discussed as clinically adapted, efficient tools for potential gene-based medicines in a variety of articular cartilage disorders. Taken as a whole, such advances in basic research in diverse fields of articular cartilage repair may lead to the development of improved therapies in the clinics for an improved, effective treatment of cartilage lesions in a close future.