High-resolution venography of the brain using magnetic resonance imaging
High-resolution venography of the brain using magnetic resonance imaging
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DOI：
10.1016/s1352-8661(98)00011-8
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发表时间：
1998-08-01
影响因子：
2.3
通讯作者：
Schad, Lothar R.
中科院分区：
文献类型：
--
作者：
Reichenbach, Juergen R. .;Essig, Marco;Schad, Lothar R.
这项研究的目的是评估一种非血流相关的磁共振成像方法，以显示人脑中独立于动脉的小静脉。使用长TE、高分辨率3D梯度回波MR采集来突出静脉信息。该方法是基于脱氧血红蛋白的顺磁性，以及在长回声时间下静脉和脑实质之间产生的相位差。为了增强小结构的可见性，用相位掩模滤波器掩蔽了MR幅度图像。静脉信息可以精确到几百微米的亚像素血管直径。使用最小强度投影算法以血管造影的方式显示静脉数据。浅静脉和深白质静脉均可见。该方法已在志愿者中成功应用。在脑动静脉畸形患者中的初步结果表明，它在临床应用中具有潜力。所提出的方法易于实现，并且不需要使用造影剂或应用专门设计的RF脉冲来突出静脉。相反，它利用了静脉血液的内在磁性(BOLD效应)和延长的T-2*。该方法可用于动静脉畸形或其他血管静脉病变的诊断。(C)1998 Elsevier Science B.V.保留所有权利。
The purpose of this study was to evaluate a non-flow related magnetic resonance imaging method to visualize small veins independent of arteries in the human brain. A long TE, high-resolution 3D gradient echo MR acquisition was used to highlight venous information. The method is based on the paramagnetic property of deoxyhemoglobin and the resulting phase difference between veins and brain parenchyma at long echo times. The MR magnitude images were masked with a phase mask filter to enhance small structure visibility.. Venous information down to sub-pixel vessel diameters of several hundred microns is visible. Venous data are displayed in an angiographic manner using a minimum intensity projection algorithm. Both superficial veins and deep white matter veins are visible. The method has been successfully applied in volunteers. Preliminary results in patients with cerebral arteriovenous malformations indicate its potential in clinical applications. The proposed method is easy to implement and does not require administration of a contrast agent or application of specially designed rf pulses to highlight the veins. Rather it exploits the intrinsic magnetic properties (BOLD-effect) and the prolonged T-2* of venous blood. The method may be of diagnostic potential in the assessment of arteriovenous malformations or other vascular venous lesions. (C) 1998 Elsevier Science B.V. All rights reserved.