Pathologic function and therapeutic potential of exosomes in cardiovascular disease.
Pathologic function and therapeutic potential of exosomes in cardiovascular disease.
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DOI：
10.1016/j.bbadis.2014.10.008
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发表时间：
2015-01
影响因子：
6.2
通讯作者：
Fan, Guo-Chang
中科院分区：
文献类型：
--
作者：
Ailawadi, Shaina;Wang, Xiaohong;Gu, Haitao;Fan, Guo-Chang
心脏是各种不同细胞类型之间有组织的相互作用的非常复杂的聚集体，这些细胞类型都有助于通过收缩性、充分灌注和细胞间接收来促进心肌功能。为了确保心脏的所有功能有效地工作，必须在不同类型的细胞之间建立一个良好的控制通信系统。心脏调节自身的最重要方式之一是使用细胞外囊泡，更具体地说，是外泌体。外泌体是一种纳米囊泡，从活细胞中自然释放出来。它们被认为通过某些机制在细胞间通讯中发挥关键作用，包括直接细胞与细胞接触，远程信号以及电和细胞外化学分子。外泌体含有许多独特的特征，如表面蛋白/受体、脂质、mRNA、microRNA、转录因子和其他蛋白质。最近的研究表明，外泌体的内容是高度调节的各种压力和疾病的条件下，反过来反映了母细胞的状态。目前，外泌体在肿瘤和感染性疾病的发生发展中发挥着重要作用。然而，对心脏外泌体的研究才刚刚兴起。本文综述了近年来外来体对应激和疾病状态下心脏重构的病理影响，包括心肌肥厚、围产期心肌病、糖尿病心肌病和脓毒症引起的心血管功能障碍。此外，还总结了应激预处理的外泌体和干细胞来源的外泌体的心脏保护作用。最后，我们讨论了如何在宿主细胞中表观遗传地重新编程外泌体内容物，使其对心脏有益。
The heart is a very complex conglomeration of organized interactions between various different cell types that all aid in facilitating myocardial function through contractility, sufficient perfusion, and cell-to-cell reception. In order to make sure all features of the heart work effectively, it is imperative to have a well-controlled communication system among the different types of cells. One of the most important ways the heart regulates itself is by the use of extracellular vesicles, more specifically, exosomes. Exosomes are types of nano-vesicles, naturally released from living cells. They are believed to play a critical role in intercellular communication through the means of certain mechanisms including direct cell-to-cell contact, long-range signals as well as electrical and extracellular chemical molecules. Exosomes contain many unique features like surface proteins/receptors, lipids, mRNAs, microRNAs, transcription factors and other proteins. Recent studies indicate that the exosomal contents are highly regulated by various stress and disease conditions, in turn reflective of the parent cell status. At present, exosomes are well appreciated to be involved in the process of tumor and infection disease. However, the research on cardiac exosomes is just emerging. In this review, we summarize recent findings on the pathologic effects of exosomes on cardiac remodeling under stress and disease conditions, including cardiac hypertrophy, peripartum cardiomyopathy, diabetic cardiomyopathy and sepsis-induced cardiovascular dysfunction. In addition, the cardio-protective effects of stress-preconditioned exosomes and stem cell-derived exosomes are also summarized. Finally, we discuss how to epigenetically reprogram exosome contents in host cells which makes them beneficial for the heart.
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影响因子：
3.7
作者：
Davis DR;Zhang Y;Smith RR;Cheng K;Terrovitis J;Malliaras K;Li TS;White A;Makkar R;Marbán E
通讯作者：
Marbán E
影响因子：
13.6
作者：
Doroudgar S;Glembotski CC
通讯作者：
Glembotski CC
影响因子：
3.7
作者：
Feng Y;Huang W;Wani M;Yu X;Ashraf M
通讯作者：
Ashraf M
影响因子：
5
作者：
Fan GC;Kranias EG
通讯作者：
Kranias EG
影响因子：
4
作者：
Colombo, Marina;Moita, Catarina;Raposo, Graca
通讯作者：
Raposo, Graca