FOOD-DEPRIVATION AFFECTS EXTINCTION AND REINSTATEMENT OF RESPONDING IN RATS
FOOD-DEPRIVATION AFFECTS EXTINCTION AND REINSTATEMENT OF RESPONDING IN RATS
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DOI：
10.1007/bf02245624
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发表时间：
1995-09-01
影响因子：
3.4
通讯作者：
CARROLL, ME
中科院分区：
文献类型：
--
作者：
COMER, SD;LAC, ST;CARROLL, ME
研究表明，食物匮乏会增加许多不同物种对多种药物的自我给药。然而，食物剥夺对吸毒其他阶段的影响尚未确定。本研究的目的是评估食物剥夺对恢复有反应的可卡因的影响。大鼠训练，自我管理0.2，0.4，或1.0毫克/公斤可卡因静脉注射（IV）下的固定比例1时间表的前2小时在每天7小时的会议之前或之后的实验会议。在3-7小时期间，大鼠自我施用盐水。在第4小时开始时，用生理盐水代替输注泵中的可卡因。在整个7小时疗程中测量自我给药的输注次数。在第1和第2小时，当可卡因可用时，输注次数与可卡因剂量呈负相关。在第3小时期间，大鼠通常自我给予几次盐水输注，其在第4-7小时逐渐降低至接近零的水平（消退响应）。在第4小时开始时给予可卡因的引发注射以剂量相关的方式恢复反应。无论可卡因维持剂量如何，在第3小时消退反应的幅度和在第4小时恢复反应的幅度相似。然而，在第4小时期间，当大鼠在会议之前与之后喂食时，所有可卡因维持剂量组的反应确实增加。还在维持0.4 mg/kg可卡因的大鼠中评估了食物剥夺水平（8-12 g，20 g，无限制食物）和喂食时间（给药前与给药后）的影响。虽然在第4小时期间反应恢复的幅度不随食物水平而变化，但在第3小时期间，当在该阶段后喂食时，维持在最低食物水平（8-12）g的大鼠的消退反应显著增加。这些结果表明，食物剥夺水平和喂养时间，而不是可卡因维持剂量，是改变灭绝和恢复的重要变量。
Food deprivation has been shown to increase the self-administration of a wide variety of drugs in a number of different species. However, the effects of food deprivation of other phases of drug taking have not been established. The purpose of the present study was to evaluate the effects of food deprivation of reinstatement of responding cocaine. Rats trained to self-administer 0.2, 0.4, or 1.0 mg/kg cocaine intravenously (IV) under a fixed-ratio 1 schedule for the first 2 h during daily 7-h sessions were fed either before or after the experimental session. During hours 3-7, rats self-administered saline. Saline replaced cocaine in the infusion pumps at the beginning of hour 4. The number of infusions that was self-administered was measured throughout the 7-h session. During hours 1 and 2 when cocaine was available, the number of infusion was inversely related to cocaine dose. During hour 3, rats typically self-administered several infusions of saline, which gradually decreased to near-zero levels by hours 4-7 (extinction responding). A priming injection of cocaine administered at the beginning of hour 4 reinstated responding in a dose-related manner. The magnitude of extinction responding during hour 3 and reinstatement of responding during hour 4 were similar regardless of cocaine maintenance dose. However, responding during hour 4 did increase in all cocain maintenance dose groups when rats were fed before versus after the session. The effects of food deprivation level (8-12 g, 20 g, unlimited food) and time of feeding (before versus after the session) were also assessed in rats maintained at 0.4 mg/kg cocaine. While the magnitude of reinstatement of responding during hour 4 did not vary as a function of food level, extinction responding during hour 3 hour was significantly increased in rats maintained at the lowest food level (8-12) g when feeding occurred after the session. These results suggest that food deprivation level and time of feeding, but not cocaine maintenance dose, are important variables in altering extinction and reinstatement of responding.