Bone mineral density of total body, spine, and femoral neck in children and young adults: A cross‐sectional and longitudinal study
Bone mineral density of total body, spine, and femoral neck in children and young adults: A cross‐sectional and longitudinal study
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儿童和年轻人全身、脊柱和股骨颈的骨矿物质密度：横断面和纵向研究
DOI：
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发表时间：
1994
影响因子：
6.2
通讯作者：
C. Cowell
中科院分区：
文献类型：
--
作者：
P. Lu;J. Briody;Graham D. Ogle;K. Morley;I. Humphries;J. Allen;R. Howman‐Giles;D. Sillence;C. Cowell
采用双能X线骨密度仪（DXA）测量了266例4 - 27岁（平均13岁）正常受试者（136例男性）的全身（TBMD）、腰椎（L2 - 4）和股骨颈的骨密度（BMD）。所有部位的BMD均随年龄显著增加，男性至17.5岁，女性至15.8岁，女性股骨颈BMD除外，其峰值出现在14.1岁。男性的TBMD峰值更高，这归因于更大的体重和瘦肉组织质量。相比之下，尽管时间较晚，但男性L2 - 4峰值BMD与女性无差异。在峰值BMD之前，体重是男女TBMD和L2 - 4 BMD的最佳预测因子（r2范围为0.77 - 0.88），而股骨颈BMD由身高和体重同等预测。从其中53名（25名男孩）4 - 16.9岁儿童中收集的纵向信息显示，男孩TBMD的平均年增量为0.047 g/cm 2，女孩为0.039 g/cm 2。两种性别的横断面和纵向数据之间年龄和BMD（斜率）之间的相关性无显著差异。我们的结论是，峰值骨密度的时间是一致的全身，腰椎，股骨颈为每个性别。女性的骨密度峰值较早很可能与青春期较早有关。本研究的横断面规范性数据可作为健康和疾病状态系列评估的标准。
Bone mineral density (BMD) of total body (TBMD), lumbar spine (L2‐4), and femoral neck was measured in 266 normal subjects (136 males) aged 4‐27 years (mean 13 years) using dual‐energy x‐ray absorptiometry (DXA). BMD of all sites increased significantly with age until 17.5 years in males and 15.8 years in females, except for femoral neck BMD in females, which peaked at age 14.1 years. Males had higher peak TBMD, which was attributed to greater weight and lean tissue mass. In contrast, despite a later timing, peak L2‐4 BMD in males was not different from that in females. Before peak BMD, weight was the best predictor of TBMD and L2‐4 BMD in both sexes (r2 ranged from 0.77 to 0.88), whereas femoral neck BMD was predicted equally by height and weight. Longitudinal information collected from 53 (25 boys) of these children, aged 4‐16.9 years, showed that the average annualized gain in TBMD was 0.047 g/cm2 for boys and 0.039 g/cm2 for girls. No significant difference in the association between age and BMD (slopes) was found between cross‐sectional and longitudinal data for either sex. We conclude that the timing for peak BMD was consistent for total body, lumbar spine, and femoral neck for each sex. The earlier peak BMD in females is most likely related to earlier puberty. The cross‐sectional normative data of this study are useful in serving as a standard for serial assessment in health and disease states.
DOI：
10.1210/jcem.75.2.1639940
发表时间：
1992
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
Lloyd,T;Rollings,N;Andon,MB;Demers,LM;Eggli,DF;Kieselhorst,K;Kulin,H;Landis,JR;Martel,JK;Orr,G
通讯作者：
Orr,G