Isolation and structure of the human cancer cell growth inhibitory cyclodepsipeptide dolastatin 16
Isolation and structure of the human cancer cell growth inhibitory cyclodepsipeptide dolastatin 16
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DOI：
10.1021/np9700230
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发表时间：
1997-08-01
影响因子：
5.1
通讯作者：
Boyd, MR
中科院分区：
文献类型：
--
作者：
Pettit, GR;Xu, JP;Boyd, MR
通过对巴布亚新几内亚产的海兔Dolabella aurcularia的研究，发现了一种新的环磷酰胺多肽Dolastatin 16(3)，其中含有两个新的氨基酸单位，分别命名为多拉甲基亮氨酸(DML)和多拉夫林(DPV)。通过高场(500MHZ)核磁共振和串联MS/MS质谱学方法对其结构进行了解析，并对其进行了cyclo-(Pro-Dpv-Pro-Dml-O-Lac-Pro-O-Hiv-MeVal).归属新的去脂肽对多种人类癌细胞具有很强的生长抑制作用。
An investigation of the sea hare Dolabella auricularia from Papua New Guinea has led to discovery of the new cyclodepsipeptide dolastatin 16 (3) containing two new amino acid units designated dolamethylleuine (Dml) and dolaphenvaline (Dpv). The structural elucidation was achieved by means of high-field (500 MHz) NMR and tandem MS/MS mass spectral interpretations and allowed the assignment cyclo-(Pro-Dpv-Pro-Dml-O-Lac-Pro-O-Hiv-MeVal). The new depsipetide exhibited strong inhibition of growth against a variety of human cancer cell lines.