SERUM CHOLESTEROL ESTERS AND INTESTINAL CHOLESTEROL SECRETION AND ABSORPTION IN OBSTRUCTIVE JAUNDICE DUE TO CANCER
SERUM CHOLESTEROL ESTERS AND INTESTINAL CHOLESTEROL SECRETION AND ABSORPTION IN OBSTRUCTIVE JAUNDICE DUE TO CANCER
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DOI：
10.1056/nejm195908202610802
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发表时间：
1959-01-01
影响因子：
158.5
通讯作者：
CHENG, SH
中科院分区：
文献类型：
--
作者：
STANLEY, MM;PINEDA, EP;CHENG, SH
在86例胰腺癌、胆囊癌、壶腹癌和不同部位肝转移癌患者中，血清总胆固醇、游离胆固醇和酯胆固醇浓度与黄疸程度相关。黄疸患者的特征性异常是血清游离胆固醇升高，酯分数降低，通常酯的绝对量降低。血清胆固醇酯的百分比通常与黄疸的程度成反比。非黄疸患者血清胆固醇酯正常。测定血清胆固醇作为酯的比例作为“肝功能试验”和黄疸的鉴别诊断是没有价值的。在这2名患者中，肠粘膜细胞的胆固醇“分泌”为每天400 mg。这些测定是对人体内这一功能大小的唯一可用的估计。
In 86 patients with cancers of the pancreas, gall bladder and ampulla of Vater, and metastases to the liver from various sites, the serum concentrations of total, free and ester cholesterol and intensity of jaundice were correlated. In jaundiced patients the characteristic abnormalities were a rise in serum free cholesterol, a decrease in ester fraction and usually a decrease in the absolute quantity of ester. The percentage of serum cholesterol esters usually was inversely proportional to the degree of jaundice. In nonjaundiced patients the serum cholesterol esters were normal. Determination of the proportion of serum cholesterol as the ester is of no value as a "liver-function test" and in the differential diagnosis of jaundice. The "secretion" of cholesterol by the mucosal cells of the intestine was 400 mg per day in these 2 patients. These determinations are the only available estimations of the magnitude of this function in man.