ULTRASTRUCTURAL EVIDENCE OF DIRECTED CELL-MIGRATION DURING INITIAL CEMENTOBLAST DIFFERENTIATION IN ROOT-FORMATION
ULTRASTRUCTURAL EVIDENCE OF DIRECTED CELL-MIGRATION DURING INITIAL CEMENTOBLAST DIFFERENTIATION IN ROOT-FORMATION
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DOI：
10.1111/j.1600-0765.1988.tb01371.x
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发表时间：
1988-07-01
影响因子：
3.5
通讯作者：
GARANT, PR
中科院分区：
文献类型：
--
作者：
CHO, MI;GARANT, PR
用光学显微镜和电子显微镜研究了14日龄Sprague-Dawley大鼠牙根的形成。特别关注的是初始成牙骨质细胞分化。破坏的上皮根鞘似乎是一个直接的细胞迁移的结果，由细胞的牙囊适当进行分化成prementoblasts。前成牙本质细胞迅速向牙本质发展极性，表现出丰富的细胞质细丝的主要细胞质突起。这些突起向牙本质基质生长并最终接触牙本质基质。这表明，牙囊的细胞适当的成牙骨质细胞的前体，响应于从新沉积的牙本质基质和/或基底层相关的根鞘起源的材料释放的化学引诱物质。
Root formation in 14-day-old Sprague-Dawley rats was studied by light and electron microscopy. Special attention was focused on initial cementoblast differentiation. Disruption of the epithelial root sheath appears to be a consequence of directed cell migration by cells of the dental follicle proper which undergo differentiation into precementoblasts. Precementoblasts rapidly develop polarity towards the dentin, exhibiting major cytoplasmic processes rich in cytoplasmic filaments. These processes grow toward and eventually contact the dentin matrix. It is suggested that the cells of the dental follicle proper are cementoblast precursors which respond to chemoattractant substances released from newly deposited dentin matrix- and/or basal lamina-associated material of root sheath origin.