A genome-wide association study identifies new susceptibility loci for non-cardia gastric cancer at 3q13.31 and 5p13.1
A genome-wide association study identifies new susceptibility loci for non-cardia gastric cancer at 3q13.31 and 5p13.1
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一项全基因组关联研究在 3q13.31 和 5p13.1 确定了非贲门胃癌的新易感位点
DOI：
10.1038/ng.978
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发表时间：
2011-12-01
期刊：
影响因子：
30.8
通讯作者：
Shen, Hongbing
中科院分区：
文献类型：
--
作者：
Shi, Yongyong;Hu, Zhibin;Shen, Hongbing
胃癌，包括贲门癌和非贲门癌，是全球癌症相关死亡的第二大原因。为了识别非贲门胃癌的遗传风险变异，我们对 3,279 名华裔个体（1,006 名非贲门胃癌患者和 2,273 名对照者）进行了全基因组关联研究。我们在另外 6,897 名受试者（3,288 名非贲门胃癌受试者和 3,609 名对照受试者）中复制了显着相关性。我们在 5p13.1（包括 PTGER4 和 PRKAA1 的区域中的 rs13361707；比值比 (OR) = 1.41；P = 7.6 × 10(-29)）和 3q13.31（ZBTB20 中的 rs9841504；OR = 0.76；P = 1.7）确定了两个新的非贲门胃癌易感位点× 10(-9))。插补分析还证实了之前报道的 8q24 上的 rs2294008 和 rs2976392、1q22 上的 rs4072037 和 20p13 上的 rs13042395 与汉族人群中非贲门胃癌易感性之间的关联。
Gastric cancer, including the cardia and non-cardia types, is the second leading cause of cancer-related deaths worldwide. To identify genetic risk variants for non-cardia gastric cancer, we performed a genome-wide association study in 3,279 individuals (1,006 with non-cardia gastric cancer and 2,273 controls) of Chinese descent. We replicated significant associations in an additional 6,897 subjects (3,288 with non-cardia gastric cancer and 3,609 controls). We identified two new susceptibility loci for non-cardia gastric cancer at 5p13.1 (rs13361707 in the region including PTGER4 and PRKAA1; odds ratio (OR) = 1.41; P = 7.6 × 10(-29)) and 3q13.31 (rs9841504 in ZBTB20; OR = 0.76; P = 1.7 × 10(-9)). Imputation analyses also confirmed previously reported associations of rs2294008 and rs2976392 on 8q24, rs4072037 on 1q22 and rs13042395 on 20p13 with non-cardia gastric cancer susceptibility in the Han Chinese population.