Stage-specific manipulation of a mosquito's host-seeking behavior by the malaria parasite Plasmodium gallinaceum
Stage-specific manipulation of a mosquito's host-seeking behavior by the malaria parasite Plasmodium gallinaceum
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DOI：
10.1093/beheco/13.6.816
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发表时间：
2002-11-01
影响因子：
2.4
通讯作者：
Paul, REL
中科院分区：
文献类型：
--
作者：
Koella, JC;Rieu, L;Paul, REL
我们提出的实验证据表明，疟疾寄生虫鸡疟原虫的不同阶段对其蚊媒埃及伊蚊的寻找宿主行为有不同的影响。在未受感染的蚊子中。如果蚊子摄取的血量低于阈值，则继续寻找宿主的行为，而较大的血量会抑制寻找宿主的行为。我们通过给感染和未感染的蚊子喂食不同的时间，并在30-45分钟后分析它们是否继续吸血来研究寄生虫对这种行为的影响。感染卵囊(不能传播)的蚊子阈值体积较小，不太可能返回进行进一步探测，而感染可传播子孢子的个体增加了抑制宿主寻找行为所需的阈值体积。我们的结论是，寄生虫寻找寄主行为的阶段特异性效应可能是寄生虫主动操纵以增加其传播成功率。
We present experimental evidence that different stages of the malaria parasite Plasmodium gallinaceum differentially affect the host-seeking behavior of its mosquito vector Aedes aegypti. In uninfected mosquitoes. host-seeking behavior is continued if mosquitoes have ingested less than a threshold volume of blood, whereas a larger blood meal inhibits host seeking. We investigated the parasite's effect on this behavior by feeding infected and uninfected mosquitoes for variable amounts of time and assaying 30-45 min later whether they continued their attempts at blood-feeding. Mosquitoes infected with oocysts (which cannot be transmitted) had a smaller threshold volume and were less likely to return for further probing, whereas individuals infected, with transmissible sporozoites increased the threshold volume required to inhibit host-seeking behavior. We conclude that the stage-specific effect of the parasite oil host-seeking behavior is likely to be an active manipulation by the parasite to increase its transmission success.