Molecular epidemiological analysis to assess the influence of pet-ownership in the biodiversity of Staphylococcus aureus and MRSA in dog- and non-dog-owning healthy households.
Molecular epidemiological analysis to assess the influence of pet-ownership in the biodiversity of Staphylococcus aureus and MRSA in dog- and non-dog-owning healthy households.
复制标题
分子流行病学分析，评估养宠物对养狗和不养狗的健康家庭中金黄色葡萄球菌和 MRSA 生物多样性的影响。
DOI：
10.1017/s0950268816003228
复制
发表时间：
2017
影响因子：
4.2
通讯作者：
Hoet,AE
中科院分区：
文献类型：
--
作者：
VANBalen,JC;Landers,T;Nutt,E;Dent,A;Hoet,AE
有研究表明，金黄色葡萄球菌（SA）和耐甲氧西林金黄色葡萄球菌（MRSA）的人畜共患传播可能发生在同一家庭的主人和宠物之间。然而，饲养宠物可能对主人之间传播的SA/MRSA菌株的生物多样性产生的影响尚不完全清楚。本研究的目的是进行分子流行病学分析，以评估和比较同一社区内养狗和不养狗的健康家庭中SA/MRSA菌株的多样性。对耐药、SCCmec型、USA型及克隆性进行了评估。总体而言，33.1%（165/499）的人携带SA， 2.8%（14/499）的人携带MRSA。犬中有7.1%（8/113）携带SA，但无MRSA阳性。养狗家庭与不养狗家庭SA/MRSA脉冲型多样性指数差异无统计学意义；但是，在每种类型的家庭中循环的脉冲型中仍然观察到明显的差异。此外，在57%的人类和宠物呈阳性的家庭中，观察到主人和狗同时携带相同的SA脉冲型。这些结果表明，狗确实可以参与家庭中SA/MRSA脉冲型的循环，并且宠物的存在似乎并不有利于家庭中的某些菌株。
It has been suggested that zoonotic transmission of Staphylococcus aureus (SA) and methicillin-resistant S. aureus (MRSA) can occur between owners and their pets within the same household. However, the influence that pet-ownership could have in the biodiversity of SA/MRSA strains circulating among owners is not fully understood. The objective of this study was to perform a molecular epidemiological analysis to evaluate and compare the biodiversity of SA/MRSA strains in dog-owning and non-dog-owning healthy households within the same community. Antimicrobial resistance, SCCmec type, USA type and clonality were assessed. Overall, 33·1% (165/499) of human subjects carried SA and 2·8% (14/499) carried MRSA. Among dogs, 7·1% (8/113) carried SA but none were MRSA positive. No difference was detected in the diversity index of SA/MRSA pulsotypes between dog-owning and non-dog-owning households; but, a marked variation was still observed in the pulsotypes circulating in each type of household. Additionally, simultaneous carriage of the same SA pulsotype in owner(s) and dog was observed in 57% of households with positive humans and pets. These results demonstrate that dogs can indeed participate in the circulation of SA/MRSA pulsotypes within a home and that the presence of a pet does not seem to favour certain strains within their household.