Shorter symptom assessment instruments: The condensed Memorial Symptom Assessment Scale (CMSAS)
Shorter symptom assessment instruments: The condensed Memorial Symptom Assessment Scale (CMSAS)
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DOI：
10.1081/cnv-200026487
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发表时间：
2004-01-01
影响因子：
2.4
通讯作者：
Thaler, HT
中科院分区：
文献类型：
--
作者：
Chang, VT;Hwang, SS;Thaler, HT
背景快速有效的症状评估是姑息治疗的一个重要方面。目的是确定32项记忆症状评估量表简表（MSAS-SF）中较少数量的症状是否可以传达等效的生活质量（QOL）信息。方法.分析了479名完成MSAS-SF和癌症治疗功能评估（FACT-G）的内科肿瘤患者的应答。进行典型相关分析，以评估32种MSAS-SF症状与生活质量（FACT-G领域）和临床变量[年龄、Karnofsky体力状态（KPS）、疾病分期和住院状态]的关系。在多变量模型中评估了简明MSAS（CMSAS）和FACT-G分量表与生存期的关系。结果中位年龄为67岁（范围：20-89），中位KPS为80%（范围：20-100）。141例（29%）患者的主要部位为前列腺，121例（26%）患者为肺部，53例（11%）患者为结直肠，50例（10%）患者为血液学，30例（6%）患者为头颈部，84例（18%）患者为其他。中位生存期为245天（范围：1- 2，215天）。典型相关分析确定了一个五维的生活质量因素结构。对生活质量重要的症状也与生存率显著相关，并为CMSAS提供了14个症状和3个分量表（CMSAS SUM，CMSAS PHYS和CMSAS PSYCH）的基础。在多变量分析中，CMSAS PSYCH预测生存期独立于分期、体能状态和QOL。CMSAS需要2-4分钟才能完成。结论CMSAS包含的生活质量和生存信息大致相当于原始的32个项目。
Background. Rapid and efficient symptom assessment is an important aspect of palliative care. The objective was to determine whether a smaller number of symptoms from the 32-item Memorial Symptom Assessment Scale Short-Form (MSAS-SF) could convey equivalent quality of life (QOL) information. Methods. Responses from 479 medical oncology patients who completed the MSAS-SF and the Functional Assessment Cancer Therapy (FACT-G) were analyzed. Canonical correlations were performed to assess the relationships of 32 MSAS-SF symptoms to quality of life (FACT-G domains) and clinical variables [age, Karnofsky performance status (KPS), stage of disease, and inpatient status]. The relation of the subscales of the Condensed MSAS (CMSAS) and FACT-G to survival was assessed in a multivariate model. Results. The median age was 67 years (range, 20-89) and median KPS was 80% (range, 20-100). Primary sites were prostate in 141 (29%) patients, lung in 121 (26%) patients, colorectal in 53 (11%) patients, hematologic in 50 (10%) patients, head and neck in 30 (6%) patients and other in 84 (18%) patients. Median survival was 245 days (range, 1-2,215 days). Canonical correlation analyses identified a five-dimensional QOL factor structure. Symptoms important for QOL also correlated significantly with survival and provided the basis for the CMSAS with 14 symptoms and 3 subscales (CMSAS SUM, CMSAS PHYS, and CMSAS PSYCH). In multivariate analyses, the CMSAS PSYCH predicted survival independently of stage, performance status, and QOL. The CMSAS takes 2-4 minutes to complete. Conclusion. The CMSAS contains both QOL and survival information approximately equivalent to the original 32 items.