Effects of ultraviolet radiation exposure on FOXP3+infiltration in cutaneous squamous cell carcinoma and basal cell carcinoma
Effects of ultraviolet radiation exposure on FOXP3+infiltration in cutaneous squamous cell carcinoma and basal cell carcinoma
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紫外线照射对皮肤鳞状细胞癌和基底细胞癌FOXP3浸润的影响
DOI：
10.1111/j.1600-0781.2011.00616.x
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发表时间：
2011-12-01
影响因子：
2.6
通讯作者：
Wu, Jinjin
中科院分区：
文献类型：
--
作者：
Chen, Ling;Shen, Zhu;Wu, Jinjin
目的：分析紫外线辐射 (UVR) 暴露后 FOXP3+ 浸润（癌前）皮肤癌的患病率和意义。 UVR 对 FOXP3 影响的可能途径有待讨论。背景：FOXP3+ 调节性 T 细胞 (FOXP3+ Tregs) 与皮肤鳞状肿瘤进展相关。然而，没有信息描述 UVR 暴露的皮肤癌前和恶性鳞状癌中 FOXP3+ 浸润的患病率。方法：我们通过免疫组织化学研究了 14 名 Bowen 病患者、40 名鳞状细胞癌 SCC 患者和 21 名基底细胞癌 (BCC) 患者中 FOXP3+ 浸润的患病率。 暴露于 UVR 的 Bowen 病和分化良好的鳞状细胞癌中 FOXP3+ 与总肿瘤周围浸润细胞 (FOXP3+ PCT) 的百分比显着高于未暴露于 UVR 的这些疾病（分别为 t = 3.5776，P = 0.0038；t' = 5.9214，P < 0.01）。 BCC 中色素较少部位的 FOXP3+ PCT 也高于色素部位（t = 3.369，P = 0.0032）。结论：这项研究揭示了 UVR 对皮肤（癌前）恶性肿瘤中 FOXP3+ 浸润的影响。我们的数据表明 FOXP3+ 浸润与 UVR 暴露呈正相关。该机制值得进一步研究。
Purpose: To analyze the prevalence and significance of FOXP3+ infiltration into (pre)malignant skin carcinomas following ultraviolet radiation (UVR) exposure. The possible pathways that UVR impacts on FOXP3 are to be discussed. Background: FOXP3+ regulatory T cells (FOXP3+ Tregs) are correlated to cutaneous squamous tumor progression. However, there is no information describing the prevalence of FOXP3+ infiltration in cutaneous premalignant and malignant squamous carcinomas with UVR exposure.Methods: We investigated the prevalence of FOXP3+ infiltration in 14 patients with Bowen's disease, 40 squamous cell carcinoma SCC patients and 21 patients with basal cell carcinoma (BCC) by immunohistochemistry.Results: The percentages of FOXP3+ vs. total peri-neoplasm infiltration cells (FOXP3+ PCT) were significantly higher in Bowen's disease and well-differentiated SCC that were exposed to UVR than these diseases not exposed to UVR (t = 3.5776, P = 0.0038; t' = 5.9214, P < 0.01, respectively). FOXP3+ PCT was also higher in less pigmented than pigmented sites in BCC (t = 3.369, P = 0.0032).Conclusions: This study shed some light on the effect of UVR on FOXP3+ infiltration in skin (pre) malignant carcinomas. Our data suggested that FOXP3+ infiltration was positively related to UVR exposure. The mechanisms merit further investigation.