In situ processing and distribution of intracerebrally injected OVA in the CNS
In situ processing and distribution of intracerebrally injected OVA in the CNS
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DOI：
10.1016/s0165-5728(03)00249-2
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发表时间：
2003-08-01
影响因子：
3.3
通讯作者：
Fabry, Z
中科院分区：
文献类型：
--
作者：
Ling, CY;Sandor, M;Fabry, Z
脑源性抗原的排出和保留是启动和调节中枢神经系统（CNS）免疫应答的重要因素。我们研究了脑内输注的蛋白抗原卵清蛋白（OVA）的分布、免疫加工和保留，以及随后CD 8（+）T细胞向CNS的募集。我们发现输注到CNS中的蛋白质抗原可以迅速流入颈部淋巴结并在外周启动抗原特异性免疫应答。一部分抗原也被脑实质中的CD 11b/MAC-1（+）细胞保留，在那里它们被抗原特异性CD 8（+）T细胞识别。(C)2003 Elsevier B.V保留所有权利。
Drainage and retention of brain-derived antigens are important factors in initiating and regulating immune responses in the central nervous system (CNS). We investigated distribution, immunological processing and retention of intracerebrally infused protein antigen, ovalbumin (OVA), and the subsequent recruitment of CD8(+) T cells into the CNS. We found that protein antigens infused into the CNS can drain rapidly into the cervical lymph node and initiate antigen-specific immune response in the periphery. A portion of the antigens are also retained by CD11b/MAC-1(+) cells in the brain parenchyma where they are recognized by antigen-specific CD8(+) T cells. (C) 2003 Elsevier B.V All rights reserved.