The role of maxiK channels in carotid body chemotransduction
The role of maxiK channels in carotid body chemotransduction
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DOI：
10.1016/j.resp.2006.10.010
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发表时间：
2007-07-01
影响因子：
2.3
通讯作者：
Wyatt, Christopher N.
中科院分区：
文献类型：
--
作者：
Peers, Chris;Wyatt, Christopher N.
MaxiK通道是由电压和细胞内Ca 2+激活的一类独特的K+通道。它们来自单一基因，其多样性来自广泛的剪接，并且它们的广泛分布导致它们在多种细胞功能中的含义。在颈动脉体中，已经提出它们有助于I型细胞的静息膜电位，并且也是O-2敏感的。因此，它们被认为在低氧化学转导中具有重要作用。当通道在HEK 293细胞中表达时，它们的O-2敏感性得以保留，从而允许详细研究maxiK通道的缺氧抑制的潜在候选机制。在这篇文章中，我们审查的证据和反对的重要作用，maxiK通道的化学转导。我们还考虑了不同的机制，提出了考虑缺氧通道抑制，并建议，虽然我们的理解这一重要的生理过程中取得了显着进展，近年来，仍然有重要的，未回答的问题，在颈动脉体化学感受的重要性maxiK。(c)2006 Elsevier B. V.保留所有权利。
MaxiK channels are a unique class of K+ channels activated by both voltage and intracellular Ca2+. Derived from a single gene, their diversity arises from extensive splicing, and their wide distribution has led to their implication in a large variety of cellular functions. In the carotid body, they have been proposed to contribute to the resting membrane potential of type I cells, and also to be O-2 sensitive. Thus, they have been suggested to have an important role in hypoxic chemotransduction. Their O-2 sensitivity is preserved when the channels are expressed in HEK 293 cells, permitting detailed studies of candidate mechanisms underlying hypoxic inhibition of maxiK channels. In this article, we review evidence for and against an important role for maxiK channels in chemotransduction. We also consider different mechanisms proposed to account for hypoxic channel inhibition and suggest that, although our understanding of this important physiological process has advanced significantly in recent years, there remain important, unanswered questions as to the importance of maxiK in carotid body chemoreception. (c) 2006 Elsevier B.V. All rights reserved.