GONADAL TOXICITY AFTER COMBINATION CHEMOTHERAPY FOR HODGKINS-DISEASE - COMPARATIVE RESULTS OF MOPP VS ABVD
GONADAL TOXICITY AFTER COMBINATION CHEMOTHERAPY FOR HODGKINS-DISEASE - COMPARATIVE RESULTS OF MOPP VS ABVD
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DOI：
10.1016/0277-5379(85)90088-4
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发表时间：
1985-01-01
期刊：
影响因子：
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通讯作者：
BONADONNA, G
中科院分区：
文献类型：
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作者：
VIVIANI, S;SANTORO, A;BONADONNA, G
在 53 名患有霍奇金病的男性中前瞻性评估了 2 种同等有效且无交叉耐药方案（MOPP 和 ABVD）后的性腺毒性比较。中位年龄为 29 岁（范围 16-45 岁）。 MOPP 在 28/29 名患者 (97%) 中产生无精子症，而 ABVD 在 13/24 名患者 (54%) 中诱发少精症。 MOPP 后 FSH 水平持续显着升高，而 ABVD 后其中位值保持在正常范围内。对 34 名患者重复进行了精子计数。接受 MOPP 治疗的 3/21 例患者和接受 ABVD 治疗的所有 13 例患者中，精子发生恢复。 MOPP 方案中包含的 2 种烷化剂，氮芥和丙卡巴肼会导致大多数患者不育，而 ABVD 中包含的药物与永久性性腺功能障碍无关。
The comparative gonadal toxicity following 2 equally effective and non-cross-resistant regimens (MOPP and ABVD) was prospectively evaluated in 53 males with Hodgkin''s disease. The median age was 29 yr (range 16-45 yr). MOPP produced azoospermia in 28/29 patients (97%) while ABVD induced oligoazoospermia in 13/24 patients (54%). FSH levels were consistently and significantly increased after MOPP while their median value remained within normal range after ABVD. Sperm count was repeated in 34 patients. Recovery of spermatogenesis occurred in 3/21 cases treated with MOPP and in all 13 cases given ABVD. The 2 alkylating agents, mechlorethamine and procarbazine, included in the MOPP regimen cause sterility in most patients while the drugs included in ABVD are not associated with permanent gonadal dysfunction.