Expression of vascular endothelial growth factor-A and vascular endothelial growth factor-C as prognostic factors for non-small cell lung cancer.
Expression of vascular endothelial growth factor-A and vascular endothelial growth factor-C as prognostic factors for non-small cell lung cancer.
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发表时间：
2004-06
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通讯作者：
T. Nakashima;Cheng‐long Huang;Dage Liu;K. Kameyama;D. Masuya;M. Ueno;R. Haba;H. Yokomise
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作者：
T. Nakashima;Cheng‐long Huang;Dage Liu;K. Kameyama;D. Masuya;M. Ueno;R. Haba;H. Yokomise
背景了解和控制血管生成和淋巴管生成可能导致有效的癌症治疗策略。我们研究的目的是阐明血管内皮生长因子-A（VEGF-A）和VEGF-C在非小细胞肺癌（NSCLC）中的临床价值。材料/方法采用免疫组织化学方法检测153例NSCLC患者肿瘤内VEGF-A和VEGF-C的表达。同时，我们使用CD 34免疫染色评估肿瘤血管生成。结果胃癌组织中VEGF-A阳性78例（51.0%），VEGF-C阳性64例（41.8%）。NSCLC中VEGF-A和VEGF-C的表达无相关性。VEGF-A阳性NSCLC中多血管肿瘤的频率显著高于VEGF-A阴性NSCLC（p=0.0442），而肿瘤内VEGF-C表达状态与肿瘤血管分布之间无相关性。关于NSCLC患者的生存，肿瘤内VEGF-A表达是NSCLC患者的重要预后因素之一（相对风险=2.012，p=0.0101），尤其是腺癌患者（相对风险=3.816，p=0.0025）。另一方面，肿瘤内表达VEGF-C是鳞状细胞癌患者的重要预后因素之一（相对危险度=3.946，p=0.0143）。结论肿瘤内VEGF-A表达是腺癌患者的重要预后因素之一，而肿瘤内VEGF-C表达是鳞状细胞癌患者的重要预后因素之一。VEGF家族的这些不同功能与肿瘤组织学的关系可能反映了NSCLC的临床行为。
BACKGROUND Understanding and controlling angiogenesis and lymphangiogenesis could lead to effective strategies for cancer treatment. The aim of our study was to clarify the clinical value of vascular endothelial growth factor-A (VEGF-A) and VEGF-C in non-small cell lung cancer (NSCLC). MATERIAL/METHODS One hundred and fifty-three patients with NSCLCs were studied to investigate intratumoral expression of VEGF-A and VEGF-C by immunohistochemistry. Simultaneously, we evaluated tumor angiogenesis using CD34 immunostaining. RESULTS Seventy-eight carcinomas (51.0%) were VEGF-A-positive, and 64 carcinomas (41.8%) were VEGF-C-positive. There was no correlationship between VEGF-A expression and VEGF-C expression in NSCLCs. The frequency of hypervascular tumors was significantly higher in VEGF-A-positive NSCLCs than in VEGF-A-negative NSCLCs (p=0.0442), while there was no correlation between intratumoral VEGF-C expression status and tumor vascularity. Concerning survival of NSCLC patients, intratumoral expression of VEGF-A was one of the significant prognostic factors in NSCLC patients (relative risk=2.012, p=0.0101), especially in patients with adenocarcinomas (relative risk=3.816, p=0.0025). On the other hand, intratumoral expression VEGF-C was one of the significant prognostic factors in patients with squamous cell carcinomas (relative risk=3.946, p=0.0143). CONCLUSIONS The present study demonstrated that intratumoral VEGF-A expression is one of the significant prognostic factors in patients with adenocarcinomas, and that intratumoral VEGF-C expression is one of the significant prognostic factors in patients with squamous cell carcinomas. These different functions of the VEGF family in relation to tumor histology might reflect the clinical behaviors of NSCLCs.