Ultrashort Echo-Time Magnetic Resonance Imaging Sequence in the Assessment of Systemic Sclerosis-Interstitial Lung Disease
Ultrashort Echo-Time Magnetic Resonance Imaging Sequence in the Assessment of Systemic Sclerosis-Interstitial Lung Disease
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DOI：
10.1097/rti.0000000000000637
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发表时间：
2023-03-01
影响因子：
3.3
通讯作者：
Colagrande, Stefano
中科院分区：
文献类型：
--
作者：
Landini, Nicholas;Orlandi, Martina;Colagrande, Stefano
目的：与计算机断层扫描（CT）相比，测试经导管触发的超短回波时间（UTE）螺旋VIBE-MRI序列在系统性硬化症-间质性肺病评估中的作用。材料和方法：54例SSc患者均行胸部CT和1.5T超声心动图检查.两名放射科医生独立且一致地验证了ILD的存在/不存在，并对两次扫描的ILD、磨玻璃样阴影（GGO）、网状和蜂窝样（HC）范围进行了半定量分析（sQA）。还进行了CT软件定量纹理分析（QA）。对于ILD检测，使用Cohen K系数计算阅片员内/阅片员间一致性。评估了UTE的敏感性和特异性。对于程度评估，通过Lin一致性系数（CCC）计算阅片者内/阅片者间一致性和相对于CT的UTE性能。结果：3例UTE因质量不佳而被剔除，51例受试者纳入研究。其中，42个QA分割被接受。39/51例CT诊断为ILD。在ILD诊断中，UTE阅片员内/阅片员间K分别为0.56和0.26。超声心动图的敏感性为92.8%，特异性为75.0%。CT sQA上ILD、GGO和网状影范围分别为14.8%、7.7%和7.1%，CT QA上分别为13.0%、11.2%和1.6%。HC分别为= 0.93和>= 0.88。RET程度CCC对sQA和QA分别为0.35和0.22。结论：UTE Spiral VIBE-MRI序列可准确评价系统性硬化-间质性肺病患者ILD和GGO的病变程度。
Purpose:To test respiratory-triggered ultrashort echo-time (UTE) Spiral VIBE-MRI sequence in systemic sclerosis-interstitial lung disease assessment compared with computed tomography (CT). Material and Methods:Fifty four SSc patients underwent chest CT and UTE (1.5 T). Two radiologists, independently and in consensus, verified ILD presence/absence and performed a semiquantitative analysis (sQA) of ILD, ground-glass opacities (GGO), reticulations and honeycombing (HC) extents on both scans. A CT software quantitative texture analysis (QA) was also performed. For ILD detection, intra-/inter-reader agreements were computed with Cohen K coefficient. UTE sensitivity and specificity were assessed. For extent assessments, intra-/inter-reader agreements and UTE performance against CT were computed by Lin's concordance coefficient (CCC). Results:Three UTE were discarded for low quality, 51 subjects were included in the study. Of them, 42 QA segmentations were accepted. ILD was diagnosed in 39/51 CT. UTE intra-/inter-reader K in ILD diagnosis were 0.56 and 0.26. UTE showed 92.8% sensitivity and 75.0% specificity. ILD, GGO, and reticulation extents were 14.8%, 7.7%, and 7.1% on CT sQA and 13.0%, 11.2%, and 1.6% on CT QA. HC was = 0.93 and >= 0.88, respectively. RET extent CCC were 0.35 and 0.22 against sQA and QA, respectively. Conclusion:UTE Spiral VIBE-MRI sequence is reliable in assessing ILD and GGO extents in systemic sclerosis-interstitial lung disease patients.