Asymptomatic Alzheimer's Disease: A Prodrome or a State of Resilience?
Asymptomatic Alzheimer's Disease: A Prodrome or a State of Resilience?
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DOI：
10.2174/156720511795745348
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发表时间：
2011-06-01
影响因子：
2.1
通讯作者：
Troncoso, J.
中科院分区：
文献类型：
--
作者：
Driscoll, I.;Troncoso, J.
阿尔茨海默病的神经病理特征--神经性斑块和神经原纤维缠结--并不局限于痴呆症患者。这些病理变化也可以出现在认知正常的老年人的大脑中-我们将这种情况定义为无症状阿尔茨海默病(ASYMAD)。尽管目前尚不清楚这些人是否会在临床上保持正常，存活时间更长，但他们似乎能够弥补或推迟痴呆症症状的出现。在这里，我们提供了一个历史背景，并强调了与ASYMAD相关的临床、病理和形态计量综合证据。了解这种明显无症状状态期间变化的性质可能有助于阐明预防疾病进展和维持认知健康的机制，这是一个重要的研究领域，与确定负面健康结果的风险和途径有关。
Neuritic plaques and neurofibrillary tangles, the neuropathological hallmarks of AD, are not limited to individuals with dementia. These pathologic changes can also be present in the brains of cognitively normal older adults - a condition we defined as Asymptomatic AD (ASYMAD). Although it remains unclear whether these individuals would remain clinically normal with longer survival, they seem to be able to compensate for or delay the appearance of dementia symptoms. Here, we provide a historical background and highlight the combined clinical, pathologic and morphometric evidence related to ASYMAD. Understanding the nature of changes during this apparently asymptomatic state may shed light on the mechanisms that forestall the progression of the disease and allow for maintenance of cognitive health, an important area of research that has been understudied relative to the identification of risks and pathways to negative health outcomes.