Human papillomavirus and cancer of the uterine cervix.

Human papillomavirus and cancer of the uterine cervix.
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人乳头瘤病毒和宫颈癌。

DOI:
10.1016/0090-8258(81)90066-4
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发表时间:
1981
影响因子:
4.7
通讯作者:
C. Morin
C. Morin
中科院分区:
医学2区
文献类型:
--
作者:
A. Meisels;C. Morin

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在1975年至1979年的一次大规模筛查计划中,在234,715名妇女中发现了1.69%的宫颈人乳头瘤病毒感染。在这5年中,宫颈湿疣是最常见的鳞状病变。尖锐湿疣发病年龄以30岁以下女性居多(71.16%),平均发病年龄为27.47岁,20-25岁发病率最高(2.5%)。尖锐湿疣比浸润癌早27.45年。在25.6%的不典型增生和肿瘤性病变中观察到尖锐湿疣共存。这种关联似乎缩短了恶性转化的平均时间。尖锐湿疣的流行病学行为似乎类似于发育异常,发育异常被认为是肿瘤形成的前兆。而尖锐湿疣的高消退率(68.39%)提示免疫功能低下及其他促进或协同因素是恶变的必要条件。
Human papillomavirus infection of the cervix was found in 1.69% of 234,715 women during a mass screening program during the years 1975 to 1979 inclusive. Condylomata of the cervix represent the most prevalent squamous lesion diagnosed during this 5-year period. Most of condylomata (71.16%) were found in women under 30 years of age with a mean of 27.47 years and a peak incidence of 2.5% in the 20–25 year-age group. Condylomata precede invasive carcinoma by 27.45 years. The coexistence of condylomata was observed in 25.6% of dysplastic and neoplastic lesions. This association seems to shorten the mean time for malignant transformation. The epidemiologic behavior of condylomata appears similar to dysplasia which is considered a precursor of neoplasia. However, the high regression rate of condylomata (68.39%) implies that lowered immunity and other promoting or synergistic factors are necessary for malignant conversion.
女性生殖道尖锐湿疣组织中乳头瘤病毒抗原的免疫学鉴定。
DOI: --
发表时间: 1980
影响因子: 7.2
作者:
Woodruff,JD;Braun,L;Cavalieri,R;Gupta,P;Pass,F;Shah,KV
通讯作者: Shah,KV
通过过氧化物酶-抗过氧化物酶技术确认尖锐湿疣宫颈病变的乳头瘤病毒病因。
DOI: --
发表时间: 1981
期刊: Journal of the National Cancer Institute
影响因子: --
作者:
Morin,C;Braun,L;Casas-Cordero,M;Shah,KV;Roy,M;Fortier,M;Meisels,A
通讯作者: Meisels,A