An investigation of auto-reactivity after head injury
An investigation of auto-reactivity after head injury
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DOI：
10.1016/j.jneuroim.2006.01.007
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发表时间：
2006-05-01
影响因子：
3.3
通讯作者：
Menon, D. K.
中科院分区：
文献类型：
--
作者：
Cox, A. L.;Coles, A. J.;Menon, D. K.
CNS损伤的鼠模型显示针对髓鞘抗原的自身反应性T细胞应答，与改善的神经元存活和功能恢复相关。这项初步研究首次表明，在人类创伤性脑损伤（TBI）中发生了类似的针对髓鞘的免疫反应，在40%的研究患者中观察到识别髓鞘碱性蛋白的淋巴细胞扩增。“反应性”患者在影像学上没有更大的挫伤体积，但比“无反应性”亚组更年轻，并且倾向于更有利的结局。这些发现与“有益的自身免疫”的概念是一致的。(c)2006 Elsevier B.V.保留所有权利。
Murine models of CNS injury show auto-reactive T cell responses directed at myelin antigens, associated with improved neuronal survival and functional recovery. This pilot study shows, for the first time, that similar immune responses against myelin occur in human traumatic brain injury (TBI), with an expansion of lymphocytes recognising myelin basic protein observed in 40% of patients studied. "Reactive" patients did not have greater contusion volume on imaging, but were younger than the "unreactive" subgroup and tended towards a more favorable outcome. These findings are consistent with the concept of "beneficial autoimmunity". (c) 2006 Elsevier B.V. All rights reserved.