Aggravation of asthmatic inflammation by chlorine exposure via innate lymphoid cells and CD11cintermediate macrophages
Aggravation of asthmatic inflammation by chlorine exposure via innate lymphoid cells and CD11cintermediate macrophages
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DOI：
10.1111/all.14017
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发表时间：
2020-02
期刊：
影响因子：
12.4
通讯作者：
Ji‐Su Shim;Hyun-Seung Lee;Da-Eun Park;Ji Won Lee;Boram Bae;Yuna Chang;Jihyun Kim;H. Y. Kim;Hye‐Ryun Kang
中科院分区：
文献类型：
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作者：
Ji‐Su Shim;Hyun-Seung Lee;Da-Eun Park;Ji Won Lee;Boram Bae;Yuna Chang;Jihyun Kim;H. Y. Kim;Hye‐Ryun Kang
氯作为消毒剂在日常生活中被广泛使用。然而，长期暴露于氯产品会加重过敏性TH2炎症和气道高反应性（AHR）。气道中的先天淋巴样细胞（ILCs）与病毒感染、污染和营养过剩有关，有助于哮喘的发生，但慢性氯暴露是否能激活先天免疫细胞尚不清楚。本研究旨在通过小鼠卵清蛋白（OVA）致敏/激发模型，评估氯吸入对先天免疫如ilc和巨噬细胞的影响与哮喘发生的关系。
Chlorine is widely used in daily life as disinfectant. However, chronic exposure to chlorine products aggravates allergic TH2 inflammation and airway hyperresponsiveness (AHR). Innate lymphoid cells (ILCs) in airways contribute to the inception of asthma in association with virus infection, pollution, and excess of nutrient, but it is not known whether chronic chlorine exposure can activate innate immune cells. The aim of this study was to evaluate the impact of chlorine inhalation on the innate immunity such as ILCs and macrophages in relation with the development of asthma by using murine ovalbumin (OVA) sensitization/challenge model.