Antitumor efficacy of the combination of photodynamic therapy and chemotherapy in murine tumors
Antitumor efficacy of the combination of photodynamic therapy and chemotherapy in murine tumors
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DOI：
10.1016/s0304-3835(97)00502-8
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发表时间：
1998-03-13
期刊：
影响因子：
9.7
通讯作者：
Valentini, G
中科院分区：
文献类型：
--
作者：
Canti, G;Nicolin, A;Valentini, G
光动力疗法（PDT）是基于施用肿瘤定位光敏剂，然后对肿瘤块进行光暴露。光细胞毒性效应主要是由单线态氧的产生引起的。最近，已经提出PDT与抗癌化疗联合使用，以利用任何附加的抗肿瘤作用。本文研究了光活化酞菁铝（AlS_2Pc）与抗癌药物阿霉素（ADR）和顺铂（CDDP）联合应用对小鼠肿瘤的作用。荷L1210白血病和P388淋巴瘤的小鼠用ADR或CDDP治疗，随后用PDT治疗。低剂量化疗无效，但联合抗肿瘤药物+ PDT具有显著的相加抗肿瘤作用。总之，通过这种联合治疗，我们能够大大降低抗胚细胞药物的有效剂量，从而降低其对正常宿主组织的毒性作用。(C)1998爱思唯尔科学爱尔兰有限公司
Photodynamic therapy (PDT) is based on the administration of tumor-localizing photosensitizers followed by light exposure of the tumor mass. The photocytotoxic effects are mainly caused by the generation of singlet oxygen. Recently, PDT has been proposed for use in combination with anticancer chemotherapy with a view to exploiting any additive antitumor effect. We investigated the effect of PDT with photoactivated aluminum disulfonated phthalocyanine (AlS2Pc) combined with the antiblastic drugs Adriamycin (ADR) and cisplatinum (CDDP) on murine tumors. Mice bearing L1210 leukemia and P388 lymphoma were treated with ADR or CDDP and subsequently treated with PDT. Low chemotherapy doses were ineffective, but the combination of antiblastic drugs + PDT had a significantly additive antitumor effect. In conclusion, with this combined therapy we were able to greatly reduce the effective doses of antiblastic drugs, thus lowering their toxic effects on normal host tissues. (C) 1998 Elsevier Science Ireland Ltd.