X-linked neuropathy: gene localization with DNA probes.
X-linked neuropathy: gene localization with DNA probes.
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X连锁神经病：用DNA探针进行基因定位。
DOI：
10.1002/ana.410200414
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发表时间：
1986
影响因子：
11.2
通讯作者：
Fryns,JP
中科院分区：
文献类型：
--
作者：
Fischbeck,KH;ar-Rushdi,N;Pericak-Vance,M;Rozear,M;Roses,AD;Fryns,JP
我们使用X染色体上的DNA多态性探针来研究四个X连锁神经病家族的遗传连锁。尽管临床变异，所有四个家庭表现出相同的连锁模式。我们发现证据表明，在每个家庭的连锁标记DXYS 1的近端长臂的X染色体，如其他人所报道的。我们还发现了与近端短臂上的p58-1（DXS 14）的连锁，我们只发现与染色体上其他9个标记的松散连锁或不连锁。我们的分析将这种疾病的基因缺陷定位在DXYS 1和p58-1区域，靠近X染色体的着丝粒。
We used probes for DNA polymorphisms on the X chromosome to study genetic linkage in four families with X‐linked neuropathy. Despite clinical variability, all four families showed the same linkage pattern. We found evidence in each family of linkage to the marker DXYS1 on the proximal long arm of the X chromosome, as reported by others. We also found linkage to p58—1 (DXS14) on the proximal short arm. We found only loose linkage or nonlinkage to nine other markers located elsewhere on the chromosome. Our analysis places the gene defect for this disorder in the region of DXYS1 and p58—1, near the centromere of the X chromosome.