Imaging the microanatomy of astrocyte-T-cell interactions in immune-mediated inflammation.
Imaging the microanatomy of astrocyte-T-cell interactions in immune-mediated inflammation.
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DOI：
10.3389/fncel.2013.00058
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发表时间：
2013
影响因子：
5.3
通讯作者：
Barcia C Jr
中科院分区：
文献类型：
--
作者：
Barcia C Sr;Mitxitorena I;Carrillo-de Sauvage MA;Gallego JM;Pérez-Vallés A;Barcia C Jr
星形胶质细胞在大脑中免疫介导的炎症反应中的作用比以前认为的更突出。星形胶质细胞通过多种途径对神经炎症刺激做出反应，对改变实质环境的机制做出重大贡献。特别地，星形胶质细胞信号传导诱导与浸润血细胞（如淋巴细胞）建立关键关系，这是有效免疫应答的基本过程。星形胶质细胞和T细胞之间的相互作用涉及对两种细胞类型的复杂修饰，其经历微观解剖学变化以及它们的结合和分泌结构域的重新分布。这些修饰对于不同的免疫应答是至关重要的，例如对于T细胞应答的有效性，对于这些细胞的特异性浸润和它们在脑实质中的归巢，以及对于它们与抗原呈递细胞（APC）的正确并置以形成免疫突触（IS）。在这篇文章中，我们回顾了目前的知识，T细胞和星形胶质细胞之间的相互作用的背景下，免疫介导的炎症在大脑中，基于显微解剖成像的高分辨率共聚焦显微镜和三维渲染。使用详细的技术方法研究这些动态相互作用有助于理解星形胶质细胞在炎症反应中的功能，并为新的治疗策略铺平道路。
The role of astrocytes in the immune-mediated inflammatory response in the brain is more prominent than previously thought. Astrocytes become reactive in response to neuro-inflammatory stimuli through multiple pathways, contributing significantly to the machinery that modifies the parenchymal environment. In particular, astrocytic signaling induces the establishment of critical relationships with infiltrating blood cells, such as lymphocytes, which is a fundamental process for an effective immune response. The interaction between astrocytes and T-cells involves complex modifications to both cell types, which undergo micro-anatomical changes and the redistribution of their binding and secretory domains. These modifications are critical for different immunological responses, such as for the effectiveness of the T-cell response, for the specific infiltration of these cells and their homing in the brain parenchyma, and for their correct apposition with antigen-presenting cells (APCs) to form immunological synapses (ISs). In this article, we review the current knowledge of the interactions between T-cells and astrocytes in the context of immune-mediated inflammation in the brain, based on the micro-anatomical imaging of these appositions by high-resolution confocal microscopy and three-dimensional rendering. The study of these dynamic interactions using detailed technical approaches contributes to understanding the function of astrocytes in inflammatory responses and paves the way for new therapeutic strategies.
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DOI：
10.1126/science.1226929
发表时间：
2012-11-23
期刊：
Science (New York, N.Y.)
影响因子：
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通讯作者：
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影响因子：
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作者：
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影响因子：
3.7
作者：
Barcia, Carlos;Sanderson, NicholasS. R.;Barrett, Robert J.;Wawrowsky, Kolja;Kroeger, Kurt M.;Puntel, Mariana;Liu, Chunyan;Castro, Maria G.;Lowenstein, Pedro R.
通讯作者：
Lowenstein, Pedro R.
影响因子：
25
作者：
Denise, A;Garcia, R;Sofroniew, MV
通讯作者：
Sofroniew, MV