Plasma adrenomedullin levels in asthmatic patients
Plasma adrenomedullin levels in asthmatic patients
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DOI：
10.1081/jas-100000109
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发表时间：
2001-01-01
影响因子：
1.9
通讯作者：
Hekim, N
中科院分区：
文献类型：
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作者：
Ceyhan, BB;Karakurt, S;Hekim, N
肾上腺髓质素（ADM）是从嗜铬细胞瘤中分离出来的一种新发现的内源性血管松弛肽。一些实验研究表明ADM在哮喘中起作用。本研究的目的是评估成人轻至重度哮喘患者和对照组的血浆ADM水平，并将其与肺功能检查结果和其他临床指标的结果联系起来。我们招募了16名轻度、10名中度、11名重度哮喘患者和12名健康对照。我们用RIA测定哮喘患者和健康受试者的血浆ADM浓度。我们评估了FEV1、FEV1预测%、FEV1/FVC、症状评分、IgE、ECP和早晚呼气流量峰值。哮喘组与对照组血清ADM水平差异无统计学意义，分别为26.3 +/- 24.2 pg/mL和22.9 +/- 17.6 pg/mL。此外，哮喘患者血浆ADM水平随病情加重而升高（轻度为20.7 +/- 14.4 pg/mL，中度为25.2 +/- 23.3 pg/mL，重度为35.5 +/- 33.6 pg/mL），但差异无统计学意义。哮喘组血浆ADM水平与FEV1水平呈负相关（p < 0.02, r = -0.37）。外周血嗜酸性粒细胞、IgE和ECP水平与血浆ADM水平无相关性。这些结果提示血浆中ADM浓度的测定不会对哮喘有诊断意义，但可能反映哮喘的严重程度。
Adrenomedullin (ADM) is a newly discovered endogenous vasorelaxing peptide isolated from phenochromocytoma. Some experimental studies suggest that ADM plays a role in asthma. The purposes of the present study were to assess the plasma ADM levels in adults with mild to severe asthma and controls and to correlate those with the findings on lung function test results and other clinical indices. We recruited 16 mild 10 moderate, and 11 severely asthmatic patients and 12 healthy controls. We measured the plasma concentrations of ADM in patients with asthma and in healthy subjects using RIA. We assessed FEV1, FEV1 predicted %, FEV1/FVC, symptom score, IgE, ECP, and morning and evening peak expiratory flow measurements. There was no significant difference between the asthmatic and the control group ADM levels, which were 26.3 +/- 24.2 pg/mL and 22.9 +/- 17.6 pg/tnl, respectively Furthermore, plasma ADM levels increased as the severity of the disease increased in asthmatic patients (20.7 +/- 14.4 pg/mL in mild, 25.2 +/- 23.3 pg/mL in moderate, and 35.5 +/- 33.6 pg/mL in severe asthmatics), although they did nos result in arty statistical significance. However the plasma ADM levels correlated negatively with the FEV1 levels in the asthmatic group (p < 0.02, r = -0.37). Peripheral blood eosinophilia, IgE, and ECP levels did not correlate with plasma ADM levels. These results suggest that the measurement of ADM concentration in plasma will not be of diagnostic rise in asthma, but may be a reflection of the severity of asthma.