Clinical characteristics of ischaemic renal disease
Clinical characteristics of ischaemic renal disease
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DOI：
10.1093/ndt/16.suppl_1.74
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发表时间：
2001-01-01
影响因子：
6.1
通讯作者：
Mora-Macía, J
中科院分区：
文献类型：
--
作者：
Alcázar, JM;Marín, R;Mora-Macía, J
背景随着预期寿命的延长，缺血性肾病的发生率越来越高，其特征是双肾动脉粥样硬化性狭窄。这是一项观察性多中心研究：在西班牙20家医院进行了为期14个月的随访。入选标准为双侧肾动脉狭窄> 50%且肌酸酐水平大于或等于1.5 mg/dl。所有病例均应通过动脉数字血管造影进行诊断。结果。共纳入156例患者。他们的平均年龄为68.7 +/-9岁，78.5%为男性。该组的平均肌酐值为2.9 +/-1.7 mg/dl。97.4%的病例存在持续时间为12 +/-9年的动脉高血压（BP），69.8%存在吸烟习惯，62.9%存在高胆固醇血症（大于或等于240 mg/dl），32.1%存在糖尿病。只有8%的患者体重指数大于或等于30 kg/m（2）。相关的心血管疾病非常常见：外周动脉病占67.5%，缺血性心脏病占44.8%，心功能不全占32.6%，中风占27.3%。在94.4%的患者中，病变累及双侧肾动脉，23%的患者完全梗阻。在非肥胖老年男性中，慢性肾功能不全、长期BP演变和其他水平的心血管疾病（尤其是外周动脉病）可诊断为疑似缺血性肾病。
Background. Longer life expectancy has favoured the ever more frequent development of ischaemic nephropathy characterized by the presence of atherosclerotic stenosis in both renal arteries.Methods. This is an observational and multicentre study: carried out during a 14-month follow-up period in 20 hospitals in Spain. Inclusion criteria were the presence of bilateral renal artery stenosis > 50% and a creatinine level of greater than or equal to1.5 mg/dl. The diagnosis should be made by arterial digital angiography in every case.Results. A total of 156 patients were included. Their mean age was 68.7 +/-9 years, and 78.5% were male. The mean creatinine value of the group was 2.9 +/-1.7 mg/dl. Arterial hypertension (BP) with a duration of 12 +/-9 years was present in 97.4% of the cases, smoking habits in 69.8%, hypercholesterolaemia (greater than or equal to 240 mg/dl) in 62.9% and diabetes in 32.1%. Only 8% of the patients had a body mass index greater than or equal to 30 kg/m(2). Associated cardiovascular disease was very frequent: peripheral arteriopathy in 67.5% of the cases, ischaemic cardiopathy in 44.8%, cardiac insufficiency in 32.6% and stroke in 27.3%. In 94.4% of the patients, the lesion affected both renal arteries, with complete obstruction in 23% of the cases.Conclusions. Diagnostic suspicion of ischaemic nephropathy can be established in non-obese elderly males with chronic renal insufficiency, long-term BP evolution and cardiovascular disease at other levels, above all, peripheral arteriopathy.