Social Patterning of Cumulative Biological Risk by Education and Income Among African Americans
Social Patterning of Cumulative Biological Risk by Education and Income Among African Americans
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DOI：
10.2105/ajph.2011.300444
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发表时间：
2012-07-01
影响因子：
12.7
通讯作者：
Taylor, Herman A.
中科院分区：
文献类型：
--
作者：
Hickson, DeMarc A.;Roux, Ana V. Diez;Taylor, Herman A.
目标。我们在非裔美国成年人中研究了多系统累积失调或适应负荷的社会模式。我们研究了4048名杰克逊心脏研究参与者的社会经济地位（SES）与适应负荷、神经内分泌、代谢、自主神经和免疫功能成分的综合指标的横断面关联。在非裔美国成年人中，较低的教育程度和收入与较高的适应负荷得分有关。在非裔美国妇女中，代谢和免疫方面的模式最为一致，自主神经方面的模式不太一致，神经内分泌方面的模式则不存在。在调整行为因素后，SES与总体适应负荷评分、代谢和免疫域的关联仍然存在，而且与收入的关系比教育的关系更强。有证据表明，男性行为调整后的神经内分泌维度与SES呈负相关，但免疫和自主神经成分没有明显的剂量反应趋势，代谢成分也没有相关性。研究结果支持我们的假设，即适应负荷在非裔美国女性中具有社会模式，但这种模式在非裔美国男性中不太一致。[J] .中华卫生杂志，2012;32(2):362- 369。doi: 10.2105 / AJPH.2011.300444)
Objectives. We examined the social patterning of cumulative dysregulation of multiple systems, or allostatic load, among African Americans adults.Methods. We examined the cross-sectional associations of socioeconomic status (SES) with summary indices of allostatic load and neuroendocrine, metabolic, autonomic, and immune function components in 4048 Jackson Heart Study participants.Results. Lower education and income were associated with higher allostatic load scores in African American adults. Patterns were most consistent for the metabolic and immune dimensions, less consistent for the autonomic dimension, and absent for the neuroendocrine dimension among African American women. Associations of SES with the global allostatic load score and the metabolic and immune domains persisted after adjustment for behavioral factors and were stronger for income than for education. There was some evidence that the neuroendocrine dimension was inversely associated with SES after behavioral adjustment in men, but the immune and autonomic components did not show clear dose response trends, and we observed no associations for the metabolic component.Conclusions. Findings support our hypothesis that allostatic load is socially patterned in African American women, but this pattern is less consistent in African American men. (Am J Public Health. 2012;102:1362-1369. doi:10.2105/AJPH.2011.300444)