Gonadal steroids regulate behavioral responses to pheromones by actions on a subdivision of the medial preoptic nucleus.
Gonadal steroids regulate behavioral responses to pheromones by actions on a subdivision of the medial preoptic nucleus.
复制标题
性腺类固醇通过作用于内侧视前核的细分来调节对信息素的行为反应。
DOI：
10.1016/s0006-8993(96)01348-0
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发表时间：
1997
期刊：
影响因子：
2.9
通讯作者：
Swann,JM
中科院分区：
文献类型：
--
作者：
Swann,JM
雄性仓鼠的交配行为是由信息素启动的，信息素由两个化学感觉系统检测到，这两个系统汇聚在杏仁内侧核和终纹床核上。这些区域的神经元投射到视前内侧核。这三个区域都含有雄激素受体。使用Fos作为刺激的标志，我们发现信息素刺激完整雄性的所有三个区域的神经元，但不能刺激去势的内侧视前核的大细胞分裂。由于这一区域在雄性交配行为的调节中起着关键作用，我们的结果表明，类固醇通过维持视前内侧核的大细胞分裂对信息素的反应性来调节交配。
Mating behavior in male hamsters is initiated by pheromones, detected by two chemosensory systems which converge on the medial nucleus of the amygdala and the bed nucleus of the stria terminalis. Neurons in these areas project to the medial preoptic nucleus. All three of these areas contain androgen receptors. Using Fos as a marker of stimulation we have found that pheromones stimulate neurons in all three areas in intact males but fail to stimulate the magnocellular division of the medial preoptic nucleus of castrates. As this area plays a critical role in the regulation of male mating behavior our results suggest that steroids regulate mating by maintaining the responsiveness of the magnocellular division of the medial preoptic nucleus to pheromones.