Divergent evolution in M6P/IGF2R imprinting from the Jurassic to the Quaternary
Divergent evolution in M6P/IGF2R imprinting from the Jurassic to the Quaternary
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DOI：
10.1093/hmg/10.17.1721
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发表时间：
2001-08-15
影响因子：
3.5
通讯作者：
Jirtle, RL
中科院分区：
文献类型：
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作者：
Killian, JK;Nolan, CM;Jirtle, RL
M6P/IGF2R印迹最早出现在大约1.5亿年前，当时原始动物与兽类哺乳动物发生了分化。虽然M6P/IGF2R在负鼠和啮齿动物中有明显的印记，但它在人类中的印记状态仍然不明确。目前还不清楚M6P/IGF2R印记是哺乳动物祖先的表观遗传类型，还是趋同进化的。我们在此报告了M6P/IGF2R在偶蹄目动物中的印记，与啮齿目和有袋类一样，但在北欧目、皮翅目和灵长类动物中没有印记，包括环尾狐猴和人类。这些结果是最简约的，在Euarchonta中M6P/IGF2R印记的单一祖先起源，然后是M6P/IGF2R印记的谱系特异性消失。在现存的灵长类动物中没有M6P/IGF2R印记，这是由于它在7500万年前从灵长类谱系中消失，表明该基因座的印记不容易引发人类疾病。此外，M6P/IGF2R印迹的不同进化表明，克隆等体外胚胎程序的成功可能取决于物种。
M6P/IGF2R imprinting first appeared approximately 150 million years ago following the divergence of prototherian from therian mammals. Although M6P/IGF2R is clearly imprinted in opossums and rodents, its imprint status in humans remains ambiguous. It is also still unknown if M6P/IGF2R imprinting was an ancestral mammalian epigenotype or if it evolved convergently. We report herein that M6P/IGF2R is imprinted in Artiodactyla, as it is in Rodentia and Marsupialia, but that it is not imprinted in Scandentia, Dermoptera and Primates, including ringtail lemurs and humans. These results are most parsimonious with a single ancestral origin of M6P/IGF2R imprinting followed by a lineage-specific disappearance of M6P/IGF2R imprinting in Euarchonta. The absence of M6P/IGF2R imprinting in extant primates, due to its disappearance from the primate lineage over 75 million years ago, demonstrates that imprinting at this locus does not predispose to human disease. Moreover, the divergent evolution of M6P/IGF2R imprinting predicts that the success of in vitro embryo procedures such as cloning may be species dependent.