TORSADES-DE-POINTES AS A MANIFESTATION OF MEXILETINE TOXICITY
TORSADES-DE-POINTES AS A MANIFESTATION OF MEXILETINE TOXICITY
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DOI：
10.1016/0002-8703(80)90070-8
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发表时间：
1980-01-01
影响因子：
4.8
通讯作者：
PANSINI, R
中科院分区：
文献类型：
--
作者：
COCCO, G;STROZZI, C;PANSINI, R
一名59岁的冠心病患者在口服美西律100 mg，每天4次后出现尖端扭转性心律失常，这是一种罕见的室性快速性心律失常。PR、QRS、QT间期正常。室性心律失常部分类似于S以前的室性早搏，但有相应的形态差异。血浆电解质在正常范围内。美西律在化学和电生理上与利多卡因相似，可能是导致这种心律失常的原因。美西律是一种有效的抗心律失常药物，但应列入与非典型性室性心动过速相关的药物名单。
An episode of torsades de pointes, an unusual ventricular tachyarrhythmia, developed in a 59 yr old coronary patient who was treated with 100 mg 4 times a day mexiletine orally. The PR, QRS and QT intervals were normal. The ventricular arrhythmias partly resembled the patient''s previous ventricular premature complexes, but there were relevant morphological differences. The plasma electrolytes were within normal limits. Mexiletine, which is chemically and electrophysiologically similar to lidocaine, probably caused this arrhythmia. Mexiletine is a useful antiarrhythmic drug, but should be added to the list of drugs associated with atypical ventricular tachycardia.