The Biology of Interleukin-1 and Its Relevance to Hemodialysis
The Biology of Interleukin-1 and Its Relevance to Hemodialysis
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IL-1 的生物学及其与血液透析的相关性
DOI：
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发表时间：
1983
期刊：
影响因子：
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通讯作者：
C. Dinarello
中科院分区：
文献类型：
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作者：
C. Dinarello
宿主对感染、毒性炎症和免疫挑战的反应具有非常一致的一组变化，这些变化通常被组合在一起并称为急性期反应。这种反应包括发热、负氮平衡、某些肝蛋白合成增加、血浆铁和锌水平降低以及循环中性粒细胞增加。疾病的持续存在导致急性期变化的持续，使得这些变化也可以是慢性病理过程的标志。宿主产生急性期反应的几种组分的能力是由于来自活化的单核吞噬细胞的介体肽的合成和释放，现在称为白细胞介素-1（IL-1）。在慢性血液透析中观察到的许多临床和实验室变化指示急性期反应，并且可能由IL-1介导。本文综述了IL-1的产生和生物学特性及其在宿主反应中的作用。此外，特别注意单核细胞活化和IL-1释放的重要性，这可能是血液透析的结果。
The host responds to infectious, toxic inflammatory and immunological challenges with a remarkably consistent set of changes which are often grouped together and called the acute phase response. This response includes fever, negative nitrogen balance, increased synthesis of certain hepatic proteins, decreases in plasma iron and zinc levels and increases in circulating neutrophils. The continued presence of the disease results in the persistence of acute phase changes such that these changes can also be markers of a chronic pathological process. The ability of the host to produce several components of the acute phase response is due to the synthesis and release of a mediator peptide derived from activated mononuclear phagocytes and now called interleukin-1 (IL-1). Many of the clinical and laboratory changes noted in chronic hemodialysis are indicative of an acute phase response and are probably mediated by IL-1. This review considers the production and biological properties of IL-1 and the role of this mediator in host responses. In addition, particular attention is paid to the importance of monocyte activation and IL-1 release which may be a consequence of hemodialysis.